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Progress of genome wide association study in domestic animals

文献类型： 外文期刊

作者： Zhang, Hui 1 ; Wang, Zhipeng 1 ; Wang, Shouzhi 1 ; Li, Hui 1 ;

作者机构： 1.Minist Agr, Key Lab Chicken Genet & Breeding, Harbin 150030, Peoples R China

2.Northeast Agr Univ, Coll Anim Sci & Technol, Harbin 150030, Peoples R China

关键词： Domestic animals;Genome wide association study (GWAS);Quantitative trait loci (QTL);Single-nucleotide polymorphism (SNP)

期刊名称：JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY （ 影响因子：5.032； 五年影响因子：5.922 ）

ISSN： 1674-9782

年卷期： 2012 年 3 卷

页码：

收录情况： SCI

摘要： Domestic animals are invaluable resources for study of the molecular architecture of complex traits. Although the mapping of quantitative trait loci (QTL) responsible for economically important traits in domestic animals has achieved remarkable results in recent decades, not all of the genetic variation in the complex traits has been captured because of the low density of markers used in QTL mapping studies. The genome wide association study (GWAS), which utilizes high-density single-nucleotide polymorphism (SNP), provides a new way to tackle this issue. Encouraging achievements in dissection of the genetic mechanisms of complex diseases in humans have resulted from the use of GWAS. At present, GWAS has been applied to the field of domestic animal breeding and genetics, and some advances have been made. Many genes or markers that affect economic traits of interest in domestic animals have been identified. In this review, advances in the use of GWAS in domestic animals are described.

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[1]Overview of genomic insights into chicken growth traits based on genome-wide association study and microRNA regulation. Zhang, Xiquan.

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