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Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp

文献类型： 外文期刊

作者： Yi, Yang 1 ; Liao, Sen-Tai 1 ; Zhang, Ming-Wei 1 ; Zhang, Rui-Fen 1 ; Deng, Yuan-Yuan 1 ; Yang, Bao 3 ; Wei, Zhen-Chen 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Biotech Res Inst, Minist Agr, Key Lab Funct Food, Guangzhou 510610, Guangdong, Peoples R China

2.Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China

3.Chinese Acad Sci, S China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China

关键词： longan pulp;polysaccharide-protein complex;immunomodulatory activity;immunosuppressed mice;cyclophosphamide

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN： 1420-3049

年卷期： 2011 年 16 卷 12 期

页码：

收录情况： SCI

摘要： The immunomodulatory function of longan pulp polysaccharide-protein complex (LP3) was investigated in immunosuppressed mice models. Compared with the model control, peroral administration of 100 mgkg(-1)d(-1) LP3 could significantly increase/enhance antibody production against chicken red blood cell (CRBC), concanavalin A (ConA)-induced splenocyte proliferation, macrophage phagocytosis, NK cell cytotoxicity against YAC-1 lymphoma cell, and interferon-gamma (INF-gamma) and interleukin-2 (IL-2) secretion in serum (P < 0.05). The immunomodulatory effects, except for those on splenocytes and macrophages (P > 0.05), were also observed in mice administered with 50 or 200 mgkg(-1)d(-1) LP3 (P < 0.05). The beneficial effects of 50-200 mgkg(-1)d(-1) LP3 were comparable to those of 50 mgkg(-1)d(-1) ganoderan. The strong immunomodulatory activity of LP3 confirmed its good potential as an immunotherapeutic adjuvant.

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[1]Microanalysis, Pharmacokinetics and Tissue Distribution of Polysaccharide-Protein Complexes from Longan Pulp in Mice. Min, Ting,Sun, Jie,Yi, Yang,Wang, Hong-Xun,Ai, You-Wei,Wang, Li-Mei,Yi, Yang,Wang, Hong-Xun,Wang, Li-Mei,Hang, Fei. 2015

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