文献类型: 外文期刊
作者: Xu, H. P. 1 ; Zeng, H. 1 ; Zhang, D. X. 1 ; Jia, X. L. 1 ; Luo, C. L. 2 ; Fang, M. X. 3 ; Nie, Q. H. 1 ; Zhang, X. Q. 1 ;
作者机构: 1.S China Agr Univ, Dept Anim Genet Breeding & Reprod, Guangzhou, Guangdong, Peoples R China
2.Guangdong Acad Agr Sci, Inst Anim Sci, Guangzhou, Guangdong, Peoples R China
3.Jinan Univ, Coll Med, Dept Lab Anim Sci, Guangzhou, Guangdong, Peoples R China
关键词: Association analysis;Chicken;Polymorphism;QTL;Candidate gene;Egg number at 300 days of age
期刊名称:GENETICS AND MOLECULAR RESEARCH ( 影响因子:0.764; 五年影响因子:0.912 )
ISSN: 1676-5680
年卷期: 2011 年 10 卷 4 期
页码:
收录情况: SCI
摘要: We looked for variations that could be associated with chicken egg number at 300 days of age (EN300) in seven genes of the hypothalamic-pituitary-gonadal axis, including gonadotrophin-releasing hormone-I (GnRH-I), GnRH receptor (GnRHR), neuropeptide Y (NPY), dopamine D2 receptor (DRD2), vasoactive intestinal polypeptide (VIP), VIP receptor-1 (VIPR-1), prolactin (PRL), and the QTL region between 87 and 105 cM of the Z chromosome. Ten mutations in the seven genes were chosen to do marker-trait association analyses in a population comprising 1310 chickens, which were obtained from a company located in Guangdong Province of China. The C1704887T of VIPR-1 was found to have a highly significant association with EN300. The T5841629C of DRD2 and the C1715301T of VIPR-1 were significantly associated with EN300. A highly significant association was also found between the C1704887T-C1715301T haplotypes of VIPR-1 and EN300. H1H3 had the highest EN300. Four PCR-RFLP variations in the candidate QTL region were selected to investigate their genetic effects on EN300. The haplotypes of T32742468C-G32742603A in this region showed a highly significant association with EN300. Bioinformatics analyses showed that both T32742468C and G32742603A were located in intron 1 of the SH3-domain GRB2-like 2 (SH3GL2) gene. We conclude that five SNPs, including C1704887T and C1715301T of VIPR-1, T5841629C of DRD2, and T32742468C and G32742603A of SH3GL2, would be useful as markers for breeding to increase chicken EN300.
- 相关文献
作者其他论文 更多>>
-
Comprehensive analysis of miRNAs, lncRNAs, and mRNAs reveals potential players of sexually dimorphic and left-right asymmetry in chicken gonad during gonadal differentiation
作者:Zou, X.;Liu, D. W.;Zou, X.;Wang, J.;Qu, H.;Lv, X. H.;Shu, D. M.;Wang, Y.;Ji, J.;He, Y. H.;Luo, C. L.
关键词:chicken; miRNAs; lncRNAs; mRNAs; gonadal differentiation
-
Association of host genetics with intestinal microbiota relevant to body weight in a chicken F2 resource population
作者:Ji, J.;Luo, C. L.;Zou, X.;Lv, X. H.;Xu, Y. B.;Shu, D. M.;Qu, H.
关键词:chicken; gut microbiota; host genetics; body weight; F2 resource population
-
Roles of chicken growth hormone receptor antisense transcript in chicken muscle development and myoblast differentiation
作者:Xu, H. D.;Li, T.;Wang, Z.;Adu-Asiamah, P.;Leng, Q. Y.;Zheng, J. H.;Zhao, Z. H.;An, L. L.;Zhang, L.;Zhang, X. Q.
关键词:chicken; growth hormone receptor; natural antisense transcript; myoblast; differentiation
-
Effects of sodium butyrate on intestinal health and gut microbiota composition during intestinal inflammation progression in broilers
作者:Zou, X.;Ji, J.;Qu, H.;Wang, J.;Wang, Y.;Liu, T. F.;Li, Y.;Luo, C. L.
关键词:broiler; sodium butyrate; intestinal inflammation; microbiota composition
-
Effects of dietary vitamin C, vitamin E, and alpha-lipoic acid supplementation on the antioxidant defense system and immune-related gene expression in broilers exposed to oxidative stress by dexamethasone
作者:El-Senousey, H. K.;Chen, B.;Wang, J. Y.;Nie, Q. H.;El-Senousey, H. K.;Chen, B.;Wang, J. Y.;Nie, Q. H.;El-Senousey, H. K.;Atta, A. M.
关键词:alpha-lipoic acid;antioxidant;broiler;immune gene expression;vitamin C
-
In ovo injection of ascorbic acid modulates antioxidant defense system and immune gene expression in newly hatched local Chinese yellow broiler chicks
作者:El-Senousey, H. K.;Chen, B.;Wang, J. Y.;Nie, Q. H.;El-Senousey, H. K.;Chen, B.;Wang, J. Y.;Nie, Q. H.;El-Senousey, H. K.;Atta, A. M.;Mohamed, F. R.
关键词:antioxidant;ascorbic acid;broiler chick;in ovo injection;immune- related gene
-
Dextran sulphate sodium (DSS) causes intestinal histopathology and inflammatory changes consistent with increased gut leakiness in chickens
作者:Zou, X.;Ji, J.;Wang, J.;Qu, H.;Shu, D. M.;Guo, F. Y.;Luo, C. L.
关键词:Chicken; clinical signs; dextran sulphate sodium; inflammatory mediators; intestinal inflammation; model