Zearalenone Decreases Food Intake by Disrupting the Gut-Liver-Hypothalamus Axis Signaling via Bile Acids
文献类型： 外文期刊
作者： Yuan, Peiqiang 1 ; Ma, Rongman 1 ; Hu, Liang 2 ; Li, Ran 2 ; Wang, Peng 3 ; Lin, Sen 4 ; Huang, Jiancai 1 ; Wen, Hongmei 1 ; Huang, Lingjie 1 ; Li, Hua 1 ; Feng, Bin 1 ; Chen, Hong 2 ; Liu, Yuntao 2 ; Zhang, Xiaoling 1 ; Lin, Yan 1 ; Xu, Shengyu 1 ; Li, Jian 1 ; Zhuo, Yong 1 ; Hua, Lun 1 ; Che, Lianqiang 1 ; Wu, De 1 ; Fang, Zhengfeng 1 ;
作者机构： 1.Sichuan Agr Univ, Anim Nutr Inst, Key Lab Anim Dis Resistance Nutr, Minist Educ, Chengdu 611130, Peoples R China
2.Sichuan Agr Univ, Coll Food Sci, Key Lab Agr Prod Proc & Nutr Hlth Coconstruct Mini, Minist Agr & Rural Affairs, Yaan 625014, Peoples R China
3.Henan Univ Technol, Coll Biol Engn, Zhengzhou 450001, Peoples R China
4.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Key Lab Urban Agr South China, Guangzhou 510640, Peoples R China
关键词： zearalenone; bile acid metabolism; toxicity; farnesoid X receptor; food intake
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）
ISSN： 0021-8561
年卷期： 2024 年 72 卷 14 期
页码：
收录情况： SCI
摘要： Zearalenone (ZEN) is a mycotoxin that is harmful to humans and animals. In this study, female and male rats were exposed to ZEN, and the results showed that ZEN reduced the farnesoid X receptor (FXR) expression levels in the liver and disrupted the enterohepatic circulation of bile acids (BAs). A decrease in food intake induced by ZEN was negatively correlated with an increase in the level of total BAs. BA-targeted metabolomics revealed that ZEN increased glycochenodeoxycholic acid levels and decreased the ratio of conjugated BAs to unconjugated BAs, which further increased the hypothalamic FXR expression levels. Preventing the increase in total BA levels induced by ZEN via Lactobacillus rhamnosus GG intervention restored the appetite. In conclusion, ZEN disrupted the enterohepatic circulation of BAs to decrease the level of food intake. This study reveals a possible mechanism by which ZEN affects food intake and provides a new approach to decrease the toxic effects of ZEN.
- 相关文献
作者其他论文 更多>>
-
Nitrogen-salt interaction in Pennisetum giganteum: Effects on soil, rhizosphere, and ion transport processes
作者：Wang, Peng;Zhang, Chen;Li, Wenyu;Guo, Junkang;Li, Yongtao;Pei, Xu;Li, Wenyan;Zhang, Zhen;Li, Yongtao;Woon, Kok Sin;Liu, Mengxue;Zhang, Zhen;Liu, Mengxue;Zhang, Zhen;Zhang, Kun;Woon, Kok Sin
关键词：Nitrogen-salt interaction; Pennisetum giganteum; Nitrogen transformation; Rhizosphere microbial community; Ion transport
-
Effects of Glycerol Monooleate on Improving Quality Characteristics and Baking Performance of Frozen Dough Breads
作者：Liu, Haocheng;Xu, Yujuan;Wen, Jing;Xu, Zhijie;Liu, Haocheng;Yang, Jiguo;Zhou, Jinfeng;Liu, Haocheng;Si, Weili;Li, Jian;Sun, Xueke
关键词：loaf; emulsifier; water distribution; microstructure; bakery product quality
-
A spatial source-oriented and probability-based risk-assessment framework for heavy metal and PAH contamination of urban soils in Guangzhou, China
作者：Chen, Lian;Lin, Sen;Wang, Dan;Li, Zhiyi;Wang, Yuan;Wang, Zhenjiang;Xie, Minghe;Li, Gaocong;Wang, Zhenjiang
关键词：Source-sink; Probability-based; Source-oriented; Health risk assessment; Co-contamination
-
The biological functions of proanthocyanidin and its application in pig production
作者：Yu, Aiying;Chen, Lian;Wang, Dan;Li, Zhiyi;Wang, Yuan;Wang, Zhenjiang;Lin, Sen;Sun, Lingli;Sun, Lingli
关键词：proanthocyanidins; biological functions; antioxidant; anti-inflammatory; pigs
-
Effects of Proanthocyanidins on Growth Performance, Intestinal Inflammation and Barrier Function, and Bile Acid Metabolism-Related Genes in Weaned Piglets Challenged with Lipopolysaccharide
作者：Yu, Aiying;Fang, Zhengfeng;Wang, Zhenjiang;Chen, Lian;Wang, Dan;Li, Zhiyi;Wang, Yuan;Lin, Sen;Wang, Sutian;Zhao, Weiguo
关键词：proanthocyanidins; weaned piglets; growth performance; intestinal inflammation; barrier function; bile acid
-
Effects of Pile-Fermentation Duration on the Taste Quality of Single-Cultivar Large-Leaf Dark Tea: Insights from Metabolomics and Microbiomics
作者：Yang, Wanying;Ni, He;Chen, Ruohong;Sun, Lingli;Li, Qiuhua;Lai, Xingfei;Zhang, Zhenbiao;Lai, Zhaoxiang;Hao, Mengjiao;Sun, Shili;Li, Qian;Lin, Sen
关键词：dark tea; quality; taste; pile-fermentation; metabolomics; microbiomics
-
Unveiling the Regulatory Mechanism of Tibetan Pigs Adipogenesis Mediated by WNT16: From Differential Phenotypes to the Application of Multi-Omics Approaches
作者：Huang, Qiuyan;Meng, Fanming;Hong, Chun;Li, Xinming;Li, Baohong;Wu, Jie;Xin, Haiyun;Wang, Sutian;Zhang, Kunli;Lin, Sen;Hu, Chuanhuo;Zhu, Xiangxing;Tang, Dongsheng;Pei, Yangli
关键词：pigs; IMF; transcriptome; metabolome; fat deposition
