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Comparison of pathogenicity of porcine deltacoronavirus CZ2020 from cell culture and intestinal contents in 27-day-old piglets

文献类型： 外文期刊

作者： Zhang, Baotai 1 ; Zhao, Shuqing 1 ; Zhong, Chunyan 1 ; Xiao, Li 1 ; Yan, Ai 10 ; Xue, Tao 2 ; Huang, Jin 1 ; Zhou, Jinzhu 1 ; Peng, Qi 1 ; Guo, Rongli 1 ; Fan, Baochao 1 ; Liu, Chuanmin 1 ; Ni, Yanxiu 1 ; Zhu, Xing 5 ; Shu, Jianhong 11 ; Zha, Yinhe 11 ; Chen, Jin 9 ; Li, Jizong 1 ; Li, Bin 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Minist Sci & Technol, Key Lab Vet Biol Engn & Technol, Jiangsu Key Lab Food Qual& Safety,Minist Agr,State, Nanjing 210014, Jiangsu, Peoples R China

2.Linyi Univ, Sch Pharm, Linyi 276000, Peoples R China

3.Jiangsu Univ, Inst Life Sci, Sch Food & Biol Engn, Zhenjiang 212013, Peoples R China

4.Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China

5.Guizhou Univ, Coll Anim Sci, Guiyang 550025, Peoples R China

6.Nanjing Tech Univ, Sch Pharm, 21009, Nanjing, Peoples R China

7.Southwest Guizhou Vocat & Tech Coll Nationalities, Dept Biol Engn, Xingyi 562400, Peoples R China

8.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Peoples R China

9.Luduo Town Anim Husb & Vet Stn, Baoying 225817, Peoples R China

10.Zunyi Anim Dis Control Ctr, Zunyi 563000, Peoples R China

11.Zhejiang Hongsheng Biotechnol CO LTD, Shaoxing 312000, Peoples R China

12.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing 210014, Peoples R China

关键词： Porcine deltacoronavirus; Pathogenicity; 27-Day -old piglets; Intestinal contents

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.848； 五年影响因子：3.957 ）

ISSN： 0882-4010

年卷期： 2022 年 170 卷

页码：

收录情况： SCI

摘要： Porcine deltacoronavirus (PDCoV) is an emenging swine enteropathogenic coronavirus that can cause high mortality rate. It affects pigs of all ages, but most several in neonatal piglets. Little is known regarding the pathogenicity of PDCoV against 27-day-old piglets. In this study, 27-day-old piglets were experimentally infected with PDCoV CZ2020 from cell culture, the challenged piglets do not have obvious symptoms from 1 to 7 days post-challenge (DPC), while viral shedding was detected in rectal swab at 1 DPC. Tissues of small intestines displayed slight macroscopic and microscopic lesions with no viral antigen detection. On the other hand, 27-day -old piglets were infected with PDCoV from intestinal contents, the piglets developed mild to severe diarrhea, shedding increasing from 2 to 7 DPC, and developed macroscopic and microscopic lesions in small intestines with clear viral antigen confirmed by immunohistochemistry staining. Indicating the small intestine was still the major target organ in PDCoV-challenged pigs at the age of 27-day-old. Diarrhea caused by PDCoV from intestinal contents in 27-day-old piglets is less reported. Thus, our results might provide new insights into the pathogenesis of PDCoV.

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