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Chemistry and bioactivity of nobiletin and its metabolites

文献类型： 外文期刊

作者： Li, Shiming 1 ; Wang, Hong 3 ; Guo, Limin 4 ; Zhao, Hui 5 ; Ho, Chi-Tang 2 ;

作者机构： 1.Huanggang Normal Univ, Hubei Key Lab Econ Forest Germplasm Improvement &, Hubei 438000, Peoples R China

2.Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08901 USA

3.Shaklee Corp, Pleasanton, CA 94588 USA

4.Xinjiang Acad Agr Sci, Urumqi 830091, Xinjiang, Peoples R China

5.Tianjin Univ Commerce, Sch Biotechnol & Food Sci, Tianjin Key Lab Food & Biotechnol, Tianjin, Peoples R China

关键词： Nobiletin;Metabolite;Bioactivity;Polymethoxyflavone

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）

ISSN： 1756-4646

年卷期： 2014 年 6 卷

页码：

收录情况： SCI

摘要： The studies of nobiletin and other polymethoxyflavones from citrus peels become prevalent in recent years due to many well-established evidences showing their multiple efficacious biological activities. The biotransformation study of polymethoxyflavones, particularly nobiletin has emerged along with the significant findings of nobiletin bioactivity. Major nobiletin metabolites from rodent biofluids have been successfully characterized, isolated or synthesized for the evaluation of their biological activities and subsequently revealed that nobiletin metabolites demonstrate similar efficacies or more potent anti-oxidant activity and scavenging property against free radicals and in the inhibition of inflammation and cancer growth, and the prevention of metabolic syndrome and cardiovascular diseases. This review starts with basic chemistry of nobiletin and other polymethoxyflavones, highlights their biological properties and recent findings and summarizes nobiletin's biotransformation and biological activities of the main nobiletin metabolites. (C) 2013 Elsevier Ltd. All rights reserved.

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