Investigation of Antioxidant Mechanisms of Novel Peptides Derived from Asian Swamp Eel Hydrolysate in Chemical Systems and AAPH-Induced Human Erythrocytes
文献类型： 外文期刊
作者： Wang, Xiao 1 ; Chen, Bingjie 1 ; Bhullar, Khushwant S. 2 ; Yang, Hang 3 ; Luo, Xiaohu 4 ; Fu, Juan 1 ; Liu, Hongru 1 ; Su, Di 5 ; Sun, Dapeng 1 ; Qiao, Yongjin 1 ; Zhou, Wenzong 3 ;
作者机构： 1.Shanghai Acad Agr Sci, Crop Breeding & Cultivat Res Inst, Res Ctr Agr Prod Preservat & Proc, Shanghai 201403, Peoples R China
2.Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2P5, Canada
3.Shanghai Acad Agr Sci, Key Lab Integrated Rice Fish Farming Ecosyst, Minist Agr & Rural Affairs, Shanghai 201403, Peoples R China
4.Ningbo Univ, Coll Food Sci & Engn, Zhejiang Malaysia Joint Res Lab Agr Prod Proc & Nu, Ningbo 315832, Zhejiang, Peoples R China
5.Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
关键词： antioxidant peptides; Asian swamp eel; molecular docking; erythrocyte morphoprotection; non-enzymatic and enzymatic antioxidant systems
期刊名称：ANTIOXIDANTS （ 影响因子：6.6； 五年影响因子：7.3 ）
ISSN：
年卷期： 2024 年 13 卷 8 期
页码：
收录情况： SCI
摘要： Sixteen novel antioxidant peptides from Asian swamp eel (ASE) were identified in previous studies. However, their chemical and cellular antioxidant mechanisms remain unclear. Molecular docking of these peptides with ABTS and DPPH radicals revealed the critical role of hydrogen bonding and Pi-Pi stacking hydrophobic interactions between hydrophobic amino acid residues and free radicals. Residues, such as tryptophan, proline, leucine, and valine, played significant roles in these interactions. All these peptides exhibited notable erythrocyte morphoprotective effects in a model of AAPH-induced oxidative damage of human erythrocytes. Erythrocyte hemolysis was reduced primarily through the modulation of both non-enzymatic (GSH/GSSG) and enzymatic antioxidant systems (SOD, CAT, and GSH-Px) by these peptides. A decrease in levels of MDA, LDH release, and hemoglobin oxidation was observed. Among the peptides, VLYPW demonstrated superior chemical and cellular antioxidant activities, which may be attributed to its higher levels of tyrosine and tryptophan, as well as to its increased hydrophobic amino acid content.
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