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The in vitro, in vivo antifungal activity and the action mode of Jelleine-I against Candida species

文献类型： 外文期刊

作者： Jia, Fengjing 1 ; Wang, Jiayi 1 ; Peng, Jinxiu 1 ; Zhao, Ping 1 ; Kong, Ziqing; Wang, Kairong 1 ; Yan, Wenjin 1 ; Wang 1 ;

作者机构： 1.Lanzhou Univ, Sch Life Sci, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 222 Tian Shui South Rd, Lanzhou 730000, Gansu, Peoples R China

2.Lanzhou Univ, Sch Life Sci, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 222

关键词： Antimicrobial peptide;Jelleine-I;Candidiasis;Antifungal;ROS production

期刊名称：AMINO ACIDS （ 影响因子：3.52； 五年影响因子：3.6 ）

ISSN： 0939-4451

年卷期： 2018 年 50 卷 2 期

页码：

收录情况： SCI

摘要： Recently, the mortality of life-threatening fungal infections increased dramatically. However, there are few antifungals existed. Antimicrobial peptides (AMPs) as promising antifungal candidates have attracted much attention. Here, we present a small antimicrobial peptide Jelleine-I that had potent in vitro and in vivo antifungal activity. Negligible hemolytic activity and in vivo toxicity were observed. Selectivity index (SI) of Jelleine-I is at least 4.6 times higher than amphotericin B. Jelleine-I could increase the production of cellular ROS and bind with genome DNA. This may contribute to its antifungal activity. Furthermore, drug resistance is not induced when the fungal cells were repeatedly treated by Jelleine-I. In conclusion, our results suggest that Jelleine-I may have the potential to be developed as a novel antifungal agent.

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[3]Fengycin antibiotics isolated from B-FS01 culture inhibit the growth of Fusarium moniliforme Sheldon ATCC 38932. Hu, Liang Bin,Shi, Zhi Qi,Zhang, Ting,Yang, Zhi Min.

[4]D-amino acid substitution enhances the stability of antimicrobial peptide polybia-CP. Jia, Fengjing,Wang, Jiayi,Peng, Jinxiu,Zhao, Ping,Wang, Kairong,Yan, Wenjin,Wang, Rui,Kong, Ziqing. 2017

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