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Antibacterial and antibiofilm activity of phenyllactic acid against Enterobacter cloacae

文献类型： 外文期刊

作者： Liu, Fang 1 ; Wang, Fengting 1 ; Du, Lihui 2 ; Zhao, Tong 3 ; Doyle, Michael P. 3 ; Wang, Daoying 1 ; Zhang, Xinxiao 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Agr Prod Proc, Nanjing 210014, Jiangsu, Peoples R China

2.Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Collaborat Innovat Ctr Modern Grain Circulat & Sa, Key Lab Grains & Oils Qual Control & Proc, Nanjing 210023, Jiangsu, Peoples R China

3.Univ Georgia, Coll Agr & Environm Sci, Ctr Food Safety, 1109 Expt St, Griffin, GA 30223 USA

关键词： Phenyllactic acid;Biofilm;Enterobacter cloacae;Cell damage

期刊名称：FOOD CONTROL （ 影响因子：5.548； 五年影响因子：5.498 ）

ISSN： 0956-7135

年卷期： 2018 年 84 卷

页码：

收录情况： SCI

摘要： Previous studies revealed that 3-Phenyllactic acid (PLA) was an antimicrobial compound with broad-spectrum activity. In this study, the efficacy of PLA to inactivate Enterobacter cloacae planktonic cells, biofilms, and its antibacterial mechanism were evaluated. Results indicated that 1% PLA reduced E. cloacae populations by about 6 log CFU/ml for planktonic cells and by 2.83 log CFU/ml for biofilm cells after 10-min treatments. TEM images revealed the damaged cell structure and leakage of the intracellular components. The permeability of the cytoplasmic membrane of E. cloacae was increased when the treated PLA concentrations was raised. Flow cytometry analysis further revealed that almost all the bacterial cells were damaged after treatment with 1% PLA for 30 min. The damages on bacterial cell membrane in the biofilms caused by 1% PLA treatment were also observed by confocal laser scanning microscopy analysis. These findings revealed that PLA was effective in inactivating planktonic and biofilm (or biofilm-associated) E. cloacae cells mainly by the mechanisms of cell membrane damage and leakage of the intracellular components. (C) 2017 Elsevier Ltd. All rights reserved.

  • 相关文献

[1]Effects of phenyllactic acid as sanitizing agent for inactivation of Listeria monocytogenes biofilms. Liu, Fang,Du, Lihui,Zhao, Tong,Zhao, Ping,Doyle, Michael P..

[2]The lytic activity of recombinant phage lysin LysK Delta amidase against staphylococcal strains associated with bovine and human infections in the Jiangsu province of China. Zhou, Yan,Zhang, Hui,Bao, Hongduo,Wang, Ran,Wang, Xiaomeng.

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