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Identification of apoptotic pathways in zearalenone-treated mouse sertoli cells

文献类型： 外文期刊

作者： Chao, Hu-He 1 ; Wang, Lei 1 ; Ma, Hao-Hai 1 ; Zhao, Ai-Hong 3 ; Xiao, Hong-Wei 4 ; Zhang, Xi-Feng 1 ;

作者机构： 1.Qingdao Agr Univ, Coll Vet Med, Qingdao 266109, Peoples R China

2.Capital Med Univ, Beijing Obstet & Gynecol Hosp, Cent Lab, Beijing 100023, Peoples R China

3.Qingdao Acad Agr Sci, Qingdao 266100, Peoples R China

4.Hubei Acad Agr Sci, Inst Anim Husb & Vet Res, Wuhan 430064, Peoples R China

关键词： Zearalenone; Sertoli cell; Apoptosis

期刊名称：JOURNAL OF TOXICOLOGICAL SCIENCES （ 影响因子：1.792； 五年影响因子：2.067 ）

ISSN： 0388-1350

年卷期： 2022 年 47 卷 6 期

页码：

收录情况： SCI

摘要： Zearalenone (ZEN), one of the most prevalent non-steroidal oestrogenic mycotoxins, is primarily produced by Fusarium fungi. Due to its toxicity as an oestrogenic compound and wide distribution in feed and foods, the reproductive toxicology of ZEN exposure is of public concern. The aim of the present study was to investigate the effect of ZEN on Sertoli cells to identify apoptotic pathways induced by this compound. We found that ZEN reduced the viability and caused apoptosis in Sertoli cells in vitro. Notably, we observed that such effects were associated with a significant increase in reactive oxygen species (ROS) and the number of cells that showed positive staining for gamma H2AX and RAD51. enzymes essential for repairing DNA damage. There was a parallel decrease in the expression of occludin and connexin 43, proteins that are present in the testis-blood barrier and gap junctions of Sertoli cells, respectively. Overall, the present study confirms that ZEN exposure can have serious deleterious effects on mammalian Sertoli cells and offers novel insight about its molecular targets in these cells.

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