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Poly (D,L-lactide-co-glycolide) nanoparticle-entrapped vaccine induces a protective immune response against porcine epidemic diarrhea virus infection in piglets

文献类型： 外文期刊

作者： Li, Bin 1 ; Du, Luping 2 ; Yu, Zhengyu 1 ; Sun, Bing 1 ; Xu, Xiangwei 1 ; Fan, Baochao 1 ; Guo, Rongli 1 ; Yuan, Wanzhe 3 ;

作者机构： 1.Jiangsu Acad Agr Sci, Minist Agr, Inst Vet Med, Key Lab Vet Biol Engn & Technol, Nanjing 210014, Jiangsu, Peoples R China

2.Jiangsu Acad Agr Sci, Inst Vet Immunol & Engn, Nanjing 210014, Jiangsu, Peoples R China

3.Agr Univ Hebei, Coll Anim Med, Baoding 071001, Peoples R China

关键词： Porcine epidemic diarrhea virus;Killed vaccine;PLGA nanoparticle;Protective immunity

期刊名称：VACCINE （ 影响因子：3.641； 五年影响因子：3.816 ）

ISSN： 0264-410X

年卷期： 2017 年 35 卷 50 期

页码：

收录情况： SCI

摘要： Porcine epidemic diarrhea (PED) causes 80-100% mortality in neonatal piglets, and its causative agent, the porcine epidemic diarrhea virus (PEDV), poses an important threat to the swine industry worldwide. In this study, we prepared biodegradable poly (D,L-lactide-co-glycolide) (PLGA) nanoparticle-entrapped PEDV killed vaccine antigens (KAg) (PLGA-KAg). Late-term pregnant sows were intranasally inoculated with PLGA-KAg, and the mortality resulting from challenge with highly virulent PEDV was investigated in their passively immunized suckling piglets. PEDV-specific IgG and IgA antibody titers were enhanced in pregnant sows immunized with PLGA-ICAg relative to the titers in sows inoculated with KAg. Similar results were seen in the passively immunized suckling piglets of these sows. Improved lymphocyte proliferation responses and IFN-gamma levels were induced in pregnant sows immunized with PLGA-KAg compared with those vaccinated with KAg or with Montanid (TM) ISA 201 VG emulsified killed PEDV vaccine (201-KAg). Importantly, there was less piglet mortality in the group vaccinated with PLGA-KAg than in the groups vaccinated with KAg or 201-KAg. These results demonstrate that PLGA-KAg is a promising candidate vaccine that can provide protective immunity against PEDV infection in suckling piglets. (C) 2017 Elsevier Ltd. All rights reserved.

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