The immune mechanism of Mycoplasma hyopneumoniae 168 vaccine strain through dendritic cells
文献类型： 外文期刊
作者： Shen, Yumeng 1 ; Hu, Weiwei 1 ; Wei, Yanna 2 ; Feng, Zhixin 2 ; Yang, Qian 1 ;
作者机构： 1.Nanjing Agr Univ, Vet Coll, Weigang 1, Nanjing 210095, Jiangsu, Peoples R China
2.Jiangsu Acad Agr Sci, Key Lab Vet Biol Engn & Technol, Inst Vet Med, Minist Agr,Natl Ctr Engn Res Vet Bioprod, Nanjing 210014, Jiangsu, Peoples R China
关键词： Vaccine Mhp-168 strain;Dendritic cells;Immune protection
期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.741； 五年影响因子：2.955 ）
ISSN： 1746-6148
年卷期： 2017 年 13 卷
页码：
收录情况： SCI
摘要： Background: Mycoplasma hyopneumoniae (Mhp) causes porcine enzootic pneumonia, a disease that cause major economic losses in the pig industry. Dendritic cells (DCs), the most effective antigen-presenting cells, are widely distributed beneath respiratory epithelium, DCs uptake and present antigens to T cells, to initiate protective immune responses in different infections. In this study, we investigated the role of porcine DCs in vaccine Mhp-168 exposure. Results: The antigen presenting ability of DCs were improved by vaccine Mhp-168 exposure. DCs could activate T-cell proliferation by up-regulating the antigen presenting molecule MHCII expression and co-stimulatory molecule CD80/86. However, the up-regulation of IL-10 and accompany with down-regulation of IFN-gamma gene level may account for the limitation of attenuated Mhp-168 strain use as vaccine alone. Conclusion: These findings are benefit for exploring the protection mechanisms and the possible limitations of this attenuated Mhp-168 vaccine.
- 相关文献
作者其他论文 更多>>
-
Resistance patterns and molecular basis to ACCase-inhibiting herbicides
作者：Yang, Qian;Wei, Tian;Zhu, Jinlei;Lv, Min;Deng, Wei;Liu, Longwei;Yang, Xia;Li, Yongfeng
关键词：ACCase gene mutation; cross-resistance; metamifop; target site-based resistance
-
Enhancing Point-of-Care Diagnosis of African Swine Fever Virus (ASFV) DNA with the CRISPR-Cas12a-Assisted Triplex Amplified Assay
作者：Zhu, Dan;Su, Tong;Sun, Tao;Qin, Xingcai;Su, Shao;Chao, Jie;Wang, Lianhui;Zhu, Dan;Su, Tong;Sun, Tao;Qin, Xingcai;Su, Shao;Chao, Jie;Wang, Lianhui;Li, Fang;Zhao, Dongming;Bai, Yun;Shao, Guoqing;Feng, Zhixin
关键词：
-
Removal of aqueous Cr(VI) by green synthesized sulfide iron nanoparticles loaded corn straw biochar: Performance, mechanism, and DFT calculations
作者：Rong, Kun;Li, Xueping;Yang, Qian;Zhang, Zaiwang;Li, Ruimin;Zhao, Lingzi;Zheng, Huanqiang;Rong, Kun;Liu, Zhaohui;Yao, Qiang
关键词：Sulfide modification; Green synthesis; Biochar; DFT; Aqueous Cr(VI)
-
Necroptosis in Pneumonia: Therapeutic Strategies and Future Perspectives
作者：Mei, Xiuzhen;Zhang, Yuchen;Wang, Shu;Jiang, Ping;Feng, Zhixin;Zhang, Zhenzhen;Mei, Xiuzhen;Zhang, Yuchen;Wang, Shu;Wang, Hui;Chen, Rong;Ma, Ke;Yang, Yue;Feng, Zhixin;Zhang, Zhenzhen;Mei, Xiuzhen;Zhang, Yuchen;Wang, Shu;Wang, Hui;Chen, Rong;Ma, Ke;Yang, Yue;Feng, Zhixin;Zhang, Zhenzhen;Wang, Hui;Yang, Yue;Feng, Zhixin;Ma, Ke;Zhang, Chao
关键词：pneumonia; necroptosis; drug classification; programmed cell death
-
Identification of the multiple roles of enolase as an plasminogen receptor and adhesin in Mycoplasma hyopneumoniae
作者：Xie, Qingyun;Liu, Beibei;Wei, Yanna;Yu, Yanfei;Xie, Xing;Shao, Guoqing;Xiong, Qiyan;Feng, Zhixin;Xing, Huixuan;Wen, Xiaoyun;Song, Daesub
关键词：Mycoplasma hyopneumoniae; Enolase; Plasminogen; Binding and activation; Adherence and cell damage
-
A Whole-Genome Analysis of the African Swine Fever Virus That Circulated during the First Outbreak in Vietnam in 2019 and Subsequently in 2022
作者：Le, Van Phan;Trinh, Thi Bich Ngoc;Ahn, Min-Ju;Jung, Min-Chul;Le, Thi Ngoc;Jeong, Dae Gwin;Ahn, Min-Ju;Jung, Min-Chul;Le, Thi Ngoc;Kang, Jung-Ah;Jeong, Dae Gwin;Kim, Jun-Seob;Yoon, Sun-Woo;Kim, Hye Kwon;Lim, Jong-Woo;Yeom, Minjoo;Song, Daesub;Lim, Jong-Woo;Yeom, Minjoo;Song, Daesub;Na, Woonsung;Xie, Xing;Feng, Zhixin
关键词：African swine fever; next-generation sequencing; complete genome sequence; virus evolution
-
Conserved Domains in Variable Surface Lipoproteins A-G of Mycoplasma hyorhinis May Serve as Probable Multi-Epitope Candidate Vaccine: Computational Reverse Vaccinology Approach
作者：Zubair, Muhammad;Wang, Jia;Yu, Yanfei;Shao, Guoqing;Feng, Zhixin;Xiong, Qiyan;Zubair, Muhammad;Wang, Jia;Yu, Yanfei;Shao, Guoqing;Feng, Zhixin;Xiong, Qiyan;Yu, Yanfei;Shao, Guoqing;Yu, Yanfei;Xiong, Qiyan;Rasheed, Muhammad Asif;Faisal, Muhammad;Dawood, Ali Sobhy;Dawood, Ali Sobhy;Ashraf, Muhammad;Xiong, Qiyan
关键词：conserved domains; immunoinformatics; multiepitope-based vaccine; M. hyorhinis; reverse vaccinology; variable surface lipoproteins
