The immune mechanism of Mycoplasma hyopneumoniae 168 vaccine strain through dendritic cells
文献类型： 外文期刊
作者： Shen, Yumeng 1 ; Hu, Weiwei 1 ; Wei, Yanna 2 ; Feng, Zhixin 2 ; Yang, Qian 1 ;
作者机构： 1.Nanjing Agr Univ, Vet Coll, Weigang 1, Nanjing 210095, Jiangsu, Peoples R China
2.Jiangsu Acad Agr Sci, Key Lab Vet Biol Engn & Technol, Inst Vet Med, Minist Agr,Natl Ctr Engn Res Vet Bioprod, Nanjing 210014, Jiangsu, Peoples R China
关键词： Vaccine Mhp-168 strain;Dendritic cells;Immune protection
期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.741； 五年影响因子：2.955 ）
ISSN： 1746-6148
年卷期： 2017 年 13 卷
页码：
收录情况： SCI
摘要： Background: Mycoplasma hyopneumoniae (Mhp) causes porcine enzootic pneumonia, a disease that cause major economic losses in the pig industry. Dendritic cells (DCs), the most effective antigen-presenting cells, are widely distributed beneath respiratory epithelium, DCs uptake and present antigens to T cells, to initiate protective immune responses in different infections. In this study, we investigated the role of porcine DCs in vaccine Mhp-168 exposure. Results: The antigen presenting ability of DCs were improved by vaccine Mhp-168 exposure. DCs could activate T-cell proliferation by up-regulating the antigen presenting molecule MHCII expression and co-stimulatory molecule CD80/86. However, the up-regulation of IL-10 and accompany with down-regulation of IFN-gamma gene level may account for the limitation of attenuated Mhp-168 strain use as vaccine alone. Conclusion: These findings are benefit for exploring the protection mechanisms and the possible limitations of this attenuated Mhp-168 vaccine.
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