您好，欢迎访问江苏省农业科学院 机构知识库！
江苏省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Lsp family proteins regulate antibiotic biosynthesis in Lysobacter enzymogenes OH11

文献类型： 外文期刊

作者： Wang, Ruping 1 ; Xu, Huiyong 1 ; Zhao, Yangyang 1 ; Zhang, Juan 2 ; Yuen, Gary Y. 3 ; Qian, Guoliang 2 ; Liu, Fengquan 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Plant Protect, Nanjing 210014, Peoples R China

2.Nanjing Agr Univ, Coll Plant Protect, Key Lab Integrated Management Crop Dis & Pests, Minist Educ, Nanjing 210095, Jiangsu, Peoples R China

3.Univ Nebraska, Dept Plant Pathol, Lincoln, NE 68583 USA

关键词： Lysobacter;Antibiotic;Lsp;HSAF;WAP-8294A2;Regulation

期刊名称：AMB EXPRESS （ 影响因子：3.298； 五年影响因子：3.427 ）

ISSN： 2191-0855

年卷期： 2017 年 7 卷

页码：

收录情况： SCI

摘要： Ax21 family proteins have been shown to play regulatory roles in plant- and animal-pathogenic species in the bacterial family Xanthomonadaceae, but the protein have not been investigated previously in the non-pathogenic members of this bacterial family. Lysobacter enzymogenes, is a non-pathogenic species known for its capacity as a biocontrol agent of plant pathogens. It is also noted for the production of antimicrobial secondary metabolites, heat stable antifungal factor (HSAF) and WAP-8294A2, that have potential for agricultural and pharmaceutical applications. The species also displays type IV pili-dependent twitching motility and the production of multiple extracellular lytic enzymes as additional biocontrol-related traits. Here, we show that L. enzymogenes strain OH11 possesses three genes widely separated in the OH11 genome that code for unique Ax21-like proteins (Lsp). By comparing the wildtype OH11 with mutant strains having a single lsp gene or a combination of lsp genes deleted, we found that each Lsp protein individually is involved in positive regulation of HSAF and WAP-8294A2 biosynthesis, but the proteins collectively do not exert additive effects in this regulation. None of the Lsp proteins were found to influence twitching motility or the production of three extracellular lytic enzymes. This study is the first to provide evidence linking Ax21-family proteins to antibiotic biosynthesis and, hence, adds new insights into the diversity of regulatory functions of Ax21 family proteins in bacteria.

  • 相关文献

[1]LetR is a TetR family transcription factor from Lysobacter controlling antifungal antibiotic biosynthesis. Wang, Ping,Chen, Hongfu,Qian, Guoliang,Liu, Fengquan,Liu, Fengquan.

[2]Transcriptomic analysis reveals new regulatory roles of Clp signaling in secondary metabolite biosynthesis and surface motility in Lysobacter enzymogenes OH11. Wang, Yansheng,Zhao, Yuxin,Zhang, Juan,Zhao, Yangyang,Shen, Yan,Su, Zhenhe,Xu, Gaoge,Qian, Guoliang,Liu, Fengquan,Liu, Fengquan,Du, Liangcheng,Huffman, Justin M.,Venturi, Vittorio. 2014

[3]Heat-Stable Antifungal Factor (HSAF) Biosynthesis in Lysobacter enzymogenes Is Controlled by the Interplay of Two Transcription Factors and a Diffusible Molecule. Su, Zhenhe,Liu, Fengquan,Su, Zhenhe,Han, Sen,Qian, Guoliang,Liu, Fengquan,Su, Zhenhe,Han, Sen,Qian, Guoliang,Liu, Fengquan,Fu, Zheng Qing. 2018

[4]Lysobacter PilR, the Regulator of Type IV Pilus Synthesis, Controls Antifungal Antibiotic Production via a Cyclic di-GMP Pathway. Chen, Yuan,Xia, Jing,Su, Zhenhe,Xu, Gaoge,Qian, Guoliang,Liu, Fengquan,Liu, Fengquan,Gomelsky, Mark.

[5]产酶溶杆菌OH11代谢产物HSAF对梨树腐烂病的防治效果. 赵延存,李红旭,何锋,曹素芳,杨晓蕾,钱国良,刘凤权. 2017

[6]Accumulation of antibiotics and heavy metals in meat duck deep litter and their role in persistence of antibiotic-resistant Escherichia coli in different flocks on one duck farm. Zhang, X. T.,Ji, X.,Zou, X. T.,Yao, W.,Lin, Y.,Zhao, W.,Shi, Z. D.,Gu, H. R.,Gong, J. S..

[7]Transcriptional and Antagonistic Responses of Biocontrol Strain Lysobacter enzymogenes OH11 to the Plant Pathogenic Oomycete Pythium aphanidermatum. Zhao, Yangyang,Liu, Fengquan,Qian, Guoliang,Chen, Yuan,Du, Liangcheng. 2017

[8]LesR is a novel upstream regulator that controls downstream Clp expression to modulate antibiotic HSAF biosynthesis and cell aggregation in Lysobacter enzymogenes OH11. Xu, Huiyong,Zhao, Yangyang,Liu, Fengquan,Wang, Ruping,Qian, Guoliang,Fu, Zheng Qing. 2017

[9]Yield Improvement of the Anti-MRSA Antibiotics WAP-8294A by CRISPR/dCas9 Combined with Refactoring Self-Protection Genes in Lysobacter enzymogenes OH11. Yu, Lingjun,Liu, Fengquan,Yu, Lingjun,Su, Wei,Du, Liangcheng,Fey, Paul D.. 2018

[10]Type IV pilus biogenesis genes and their roles in biofilm formation in the biological control agent Lysobacter enzymogenes OH11. Xia, Jing,Chen, Jiaojiao,Chen, Yuan,Qian, Guoliang,Liu, Fengquan,Liu, Fengquan. 2018

[11]Production of Antifungal p-Aminobenzoic Acid in Lysobacter antibioticus OH13. Laborda, Pedro,Zhao, Yangyang,Ling, Jun,Hou, Rongxian,Liu, Fengquan. 2018

[12]ChpA Controls Twitching Motility and Broadly Affects Gene Expression in the Biological Control Agent Lysobacter enzymogenes. Zhou, Mimi,Shen, Danyu,Xu, Gaoge,Qian, Guoliang,Liu, Fengquan.

[13]Molecular cloning and identification of an ammonium transporter gene from pear. Li, Hui,Lin, Jing,Chang, You Hong,Cong, Yu.

作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：江苏省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台