Inhibitory effect of Malvidin on TNF-alpha-induced inflammatory response in endothelial cells
文献类型： 外文期刊
作者： Huang, Wu-Yang 1 ; Wang, Jian 1 ; Liu, Ya-Mei 3 ; Zheng, Qi-Sheng 3 ; Li, Chun-Yang 1 ;
作者机构： 1.Jiangsu Acad Agr Sci, Inst Farm Prod Proc, Dept Funct Food & Bioact Cpds, Nanjing 210014, Jiangsu, Peoples R China
2.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China
3.Jiangsu Acad Agr Sci, Natl Tech Res Ctr Vet Biol Prod, Nanjing 210014, Jiangsu, Peoples R China
关键词： Adhesion molecule;Anti-inflammation;Endothelial cells;Malvidin;NF-kappa B pathway;TNF-alpha
期刊名称：EUROPEAN JOURNAL OF PHARMACOLOGY （ 影响因子：4.432； 五年影响因子：4.014 ）
ISSN： 0014-2999
年卷期： 2014 年 723 卷
页码：
收录情况： SCI
摘要： Vascular inflammatory responses are key mediators of endothelial dysfunction that leads to various pathologies in many diseases including atherosclerosis and cancer. The purpose of the study was to investigate the effects and molecular mechanisms of Malvidin, a natural pigment with strong antioxidant activity, on regulating inflammatory response in endothelial cells. Our results showed that tumor necrosis factor-alpha (TNF-alpha) significantly increased the protein or mRNA levels of monocyte chemotactic protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1), whereas pretreatment with Malvidin inhibited TNF-alpha-induced increases of MCP-1, ICAM-1, and VCAM-1 production in a concentration-dependent manner. In addition, Malvidin could inhibit degradation of I kappa B alpha and the nuclear translocation of p65, which suggesting the anti-inflammation mechanism of Malvidin by the nuclear factor kappa B (NF-kappa B) pathway. These results indicate the potential role of Malvidin in preventing chronic inflammation in many diseases. (C) 2013 Elsevier B.V. All rights reserved.
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