Highly Sensitive and Selective DNA-Based Detection of Mercury(II) with alpha-Hemolysin Nanopore
文献类型： 外文期刊
作者： Wen, Shuang 1 ; Zeng, Tao 2 ; Liu, Lei 1 ; Zhao, Kai 1 ; Zhao, Yuliang 1 ; Liu, Xianjin 3 ; Wu, Hai-Chen 1 ;
作者机构： 1.Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
2.Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China
3.Jiangsu Acad Agr Sci, Key Lab Food Qual & Safety Jiangsu Prov, Key Lab Agrofood Safety & Qual, State Key Lab Breeding Base,Minist Agr,Inst Food, Nanjing 210014, Peoples R China
期刊名称：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY （ 影响因子：15.419； 五年影响因子：15.801 ）
ISSN： 0002-7863
年卷期： 2011 年 133 卷 45 期
页码：
收录情况： SCI
摘要： The duplex formation mediated by Hg(2+) in a properly designed ssDNA generates a stable hairpin structure, which greatly alters the translocation profile of the ssDNA through a-hemolysin nanopore. From the 2D-events contour plot, the presence of Hg(2+) can be confirmed in as little as 30 min at similar to 7 nM or higher. The sensor is highly selective to Hg(2+), without interference from other metal ions. It can be fabricated from readily available materials, without the processes of synthesis, purification, probe-making, and so forth. This sensing strategy opens new possibilities for detecting many types of analytes which have specific interactions with DNA molecules.
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