文献类型： 外文期刊
作者： Song, Yuxin 1 ; Yang, Li'ang 2 ; Jiang, Li 3 ; Hao, Zhiyu 4 ; Yang, Runqing 3 ; Xu, Pao 1 ;
作者机构： 1.Nanjing Agr Univ, Wuxi Fisheries Coll, Wuxi 214081, Jiangsu, Peoples R China
2.Northeast Agr Univ, Coll Life Sci, Harbin, Peoples R China
3.Chinese Acad Fishery Sci, Res Ctr Aquat Biotechnol, Beijing 100141, Peoples R China
4.Heilongjiang Acad Agr Sci, Inst Anim Husb, Harbin, Peoples R China
关键词： binary disease; genomic control; generalized linear mixed model; joint association analysis; computational efficiency
期刊名称：BRIEFINGS IN BIOINFORMATICS （ 影响因子：13.994； 五年影响因子：12.784 ）
ISSN： 1467-5463
年卷期： 2022 年 23 卷 1 期
页码：
收录情况： SCI
摘要： Complex computation and approximate solution hinder the application of generalized linear mixed models (GLMM) into genome-wide association studies. We extended GRAMMAR to handle binary diseases by considering genomic breeding values (GBVs) estimated in advance as a known predictor in genomic logit regression, and then reduced polygenic effects by regulating downward genomic heritability to control false negative errors produced in the association tests. Using simulations and case analyses, we showed in optimizing GRAMMAR, polygenic effects and genomic controls could be evaluated using the fewer sampling markers, which extremely simplified GLMM-based association analysis in large-scale data. Further, joint association analysis for quantitative trait nucleotide (QTN) candidates chosen by multiple testing offered significant improved statistical power to detect QTNs over existing methods.
- 相关文献
作者其他论文 更多>>
-
GRAMMAR-Lambda Delivers Efficient Understanding of the Genetic Basis for Head Size in Catfish
作者：Zhao, Yunfeng;Zhao, Yunfeng;Jiang, Li;Gao, Jin;Feng, Hong
关键词：linear mixed model; EMMAX;
Ictalurus punctatus ; morphology; genome-wide association study -
Multi-omics and biochemical analyses provide insights into hepatic glucolipid metabolism in red tilapia ( Oreochromis spp.) under salinity stress
作者：Jiang, Bingjie;Tao, Yifan;Lu, Siqi;Hua, Jixiang;Li, Yan;Dong, Yalun;Xu, Pao;Qiang, Jun;Huang, Renshan;Xu, Pao;Qiang, Jun
关键词：Glucolipid metabolism; Multi-omics; Physiological response; Red tilapia; Salinity stress
-
Genome-Wide Association Study and RNA-Seq Analysis Uncover Candidate Genes Controlling Growth Traits in Red Tilapia (Oreochromis spp.) Under Hyperosmotic Stress
作者：Jiang, Bingjie;Tao, Yifan;Lu, Siqi;Xu, Pao;Qiang, Jun;Liu, Kai;Tao, Wenjing;Badran, Mohamed Fekri;Saleh, Moustafa Hassan Lotfy;Aboueleila, Rahma Halim Mahmoud;Xu, Pao;Qiang, Jun;Liu, Kai
关键词：red tilapia; growth traits; RNA-seq; GWAS; candidate gene
-
Immune response of intestinal micrornas to transport stress in hybrid yellow catfish (tachysurus fulvidraco♀ xt. vachellii♂) : response strategy and potential biomarker
作者：Zheng, Tao;Zheng, Tao;Qiang, Jun;Xu, Pao;Zheng, Tao;Tao, Yifan;Lu, Siqi;Qiang, Jun;Xu, Pao
关键词：Transport stress; Intestine; Immune regulation; Hybrid yellow catfish; RNA sequencing
-
Gut Microbe Rikenellaceae_RC9_gut_group and Knoellia-Mediated Acetic Acid Regulates Glucose and Lipid Metabolism in the Muscle of Freshwater Drum (Aplodinotus grunniens) Under High-Fat Diets
作者：Xue, Miaomiao;Xu, Pao;Wen, Haibo;Chen, Jianxiang;Kong, Changxin;Li, Xiaowei;Wang, Hang;Guo, Xinxin;Su, Yi;Li, Hongxia;Song, Changyou;Xu, Pao;Wen, Haibo;He, Jiyan;Chen, Jianxiang;Li, Hongxia;Song, Changyou
关键词：acetic acid;
Aplodinotus grunniens ; glycolipid metabolism; gut microbes; high-fat diet; muscle -
Intestinal Microbiota and Gene Expression Alterations in Chinese Mitten Crab (Eriocheir sinensis) Under Deltamethrin Exposure
作者：Zhong, Chunyi;Du, Jinliang;Xu, Gangchun;Xu, Pao;Zhong, Chunyi;Du, Jinliang;Zhu, Haojun;Gao, Jiancao;Xu, Gangchun;Xu, Pao;Du, Jinliang
关键词：Chinese mitten crab (Eriocheir sinensis); intestinal tissue; deltamethrin; oxidative stress; intestinal microbiome
-
Rice-fish co-culture improves carp (Cyprinus carpio) quality by modulating the gut microbiota and metabolites
作者：Nie, Zhijuan;Xu, Xiaotong;Ji, Yanhan;Gao, Ping;Zhou, Sihan;He, Jian;Liu, Xu;Wang, Baozhan;Nie, Zhijuan;Sun, Yi;Wang, Lanmei;Shao, Nailing;Xu, Pao;Shi, Yu
关键词：Rice-fish co-culture; Gut microbiome; Community assembly; Network analysis
