Identification and bioactivity evaluation of ring-opening and lactone forms of enterolactone from sheep fed flaxseed cake
文献类型： 外文期刊
作者： Zhuang, Cong-Cong 1 ; Liu, Chun-Rui 1 ; Xu, Hai-Yan 1 ; Yang, Xin-Yue 1 ; Wu, Dan-Dan 1 ; Zheng, Zhong 1 ; Wang, Li-Wei 1 ; Liu, Zheng 3 ; Ma, Chao-Mei 1 ;
作者机构： 1.Inner Mongolia Univ, Sch Life Sci, Hohhot, Peoples R China
2.Inner Mongolia Acad Agr & Anim Husb Sci, Biotechnol Res Inst, Hohhot, Peoples R China
3.Inner Mongolia Yishanyuan Biotechnol Co Ltd, Hohhot, Peoples R China
关键词： Mammalian lignan; ring-opening enterolactone; pH dependent structure; breast cancer; anti-osteoporosis
期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.2； 五年影响因子：2.3 ）
ISSN： 1478-6419
年卷期： 2024 年
页码：
收录情况： SCI
摘要： The previously undescribed lactone ring-opening enterolactone and its sulphate were purified along with the lactone counterparts from the urine of dairy sheep fed flaxseed cake. The structures were determined by NMR and MS analyses. The ring-opening and lactone forms underwent mutual transformation with changes in pH and milk could protect the lactone form. Enterolactone exhibited more effective anti-proliferation activity on MDA-MB-231 breast cancer cells than its ring-opening counterpart, while the ring-opening enterolactone demonstrated more effective anti-osteoporosis activity than the lactone form. The results indicated the potential for targeting biological functions through pH and medium manipulation.
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