Characterization of the molecular, cellular, and behavioral changes caused by exposure to a saline-alkali environment in the Chinese mitten crab, Eriocheir sinensis
文献类型： 外文期刊
作者： Wang, Meiyao 1 ; Xu, Pao 1 ; Zhou, Jun 3 ; Ge, Jiachun 3 ; Xu, Gangchun 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Key Lab Freshwater Fisheries & Germplasm Resources, Minist Agr & Rural Affairs, Wuxi 214081, Peoples R China
2.Nanjing Agr Univ, Wuxi Fisheries Coll, Wuxi, Peoples R China
3.Freshwater Fisheries Res Inst Jiangsu Prov, Nanjing, Peoples R China
关键词： Climate change; Crustacean; Cerebral ganglion; Histopathology; Multi-omics profiling
期刊名称：ENVIRONMENTAL RESEARCH （ 影响因子：7.7； 五年影响因子：7.7 ）
ISSN： 0013-9351
年卷期： 2024 年 262 卷
页码：
收录情况： SCI
摘要： In the context of global warming, the accelerated evaporation of seawater will lead to a continuous expansion of saline-alkali land area. As an important economic freshwater crustacean, investigation on the mechanism of damage to Eriocheir sinensis (E. sinensis) under saline-alkali environment will provide a valuable precedent for understanding the detrimental effect of climate change on crustaceans. In this study, histopathological analysis and integrative omics analysis were employed to explore the injury mechanism on the cerebral nervous system of E. sinensis exposure to saline-alkali stress. Our findings revealed that under this stress E. sinensis exhibited behavioral disorders and damage to cerebral neurosecretory cells and key organelles. Additionally, several pathways related to detoxification metabolism, neurotransmitter synthesis, and antioxidant defense were significantly down-regulated. Collectively, these results show, for the first time, that saline-alkali stress can induce neurodegenerative disease-like symptoms in E. sinensis, and provide critical information for understanding the harmful effects of saline-alkali environments.
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