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Low particle concentrations of nanoplastics impair the gut health of medaka

文献类型： 外文期刊

作者： Zhou, Yinfeng 1 ; Gui, Lang 1 ; Wei, Wenbo 1 ; Xu, Elvis Genbo 3 ; Zhou, Wenzhong 4 ; Sokolova, Inna M. 5 ; Li, Mingyou 1 ; Wang, Youji 1 ;

作者机构： 1.Shanghai Ocean Univ, Key Lab Explorat & Utilizat Aquat Genet Resources, Minist Educ, Shanghai 201306, Peoples R China

2.Shanghai Ocean Univ, Int Res Ctr Marine Biosci, Minist Sci & Technol, Shanghai 201306, Peoples R China

3.Univ Southern Denmark, Dept Biol, DK-5230 Odense M, Denmark

4.Shanghai Acad Agr Sci, Ecoenvironm Protect Res Inst, 1000 Jinqi Rd, Shanghai 201403, Peoples R China

5.Univ Rostock, Inst Biol Sci, Dept Marine Biol, Rostock, Germany

6.Univ Rostock, Interdisciplinary Fac, Dept Maritime Syst, Rostock, Germany

关键词： Polymer; Oryzias latipes; Chronic exposure; Intestinal health; Gut microbiota

期刊名称：AQUATIC TOXICOLOGY （ 影响因子：4.5； 五年影响因子：5.2 ）

ISSN： 0166-445X

年卷期： 2023 年 256 卷

页码：

收录情况： SCI

摘要： The environmental occurrence of nanoplastics (NPs) is now evident but their long-term impacts on organisms are unclear, limiting ecological and health risk assessment. We hypothesized that chronic exposure to low particle concentrations of NPs can result in gut-associated toxicity, and subsequently affect survival of fish. Japanese medaka Oryzias latipes were exposed to polystyrene NPs (diameter 100 nm; 0, 10, 104, and 106 items/L) for 3 months, and histopathology, digestive and antioxidant enzymes, immunity, intestinal permeability, gut micro -biota, and mortality were assessed. NP exposures caused intestinal lesions, and increased intestinal permeability of the gut. The trypsin, lipase, and chymotrypsin activities were increased, but the amylase activity was decreased. Oxidative damage was reflected by the decreased superoxide dismutase and alkaline phosphatase and increased malondialdehyde, catalase, and lysozyme. The integrated biomarkers response index values of all NP -exposed medaka were significantly increased compared to the control group. Moreover, NP exposures resulted in a decrease of diversity and changed the intestinal microbiota composition. Our results provide new evidence that long-term NPs exposure impaired the health of fish at extremely low particle concentrations, suggesting the need for long-term toxicological studies resembling environmental particle concentrations when assessing the risk of NPs.

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