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Associations of GBP2 gene copy number variations with growth traits and transcriptional expression in Chinese cattle

文献类型： 外文期刊

作者： Zhang, Gui-Min 1 ; Zheng, Li 2 ; He, Hua 1 ; Song, Cheng-Chuang 1 ; Zhang, Zi-Jing 4 ; Cao, Xiu-Kai 1 ; Lei, Chu-Zhao; 1 ;

作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, 22 Xinong Rd, Yangling 712100, Shaanxi, Peoples R China

2.Henan Univ Anim Husb & Econ, Zhengzhou 450046, Henan, Peoples R China

3.Northwest A&F Univ, Coll Vet Med, Yangling 712100, Shaanxi, Peoples R China

4.Henan Acad Agr Sci, Inst Anim Husb & Vet Sci, Zhengzhou 4500

关键词： GBP2;CNVs;Association;Expression;Cattle

期刊名称：GENE （ 影响因子：3.688； 五年影响因子：3.329 ）

ISSN： 0378-1119

年卷期： 2018 年 647 卷

页码：

收录情况： SCI

摘要： Copy number variations (CNVs) recently have been recognized as another important genetic variability followed single nucleotide polymorphisms (SNPs). The guanylate binding protein 2 (GBP2) gene plays an important role in cell proliferation. This study was performed to determine the presence of GBP2 CNV (relative to Angus cattle) in 466 individuals representing six main cattle breeds from China, identify its relationship with growth, and explore the biological effects of gene expression. There were two CNV regions in the GBP2 gene, for three types, CNV1 loss type (relative to Angus cattle) was more frequent in XN than other breeds, and CNV2 loss type (relative to Angus cattle) was more frequent in XN and CDM than other breeds. Though the GBP2 gene copy number presented no correlation with the transcriptional expression of JX (P > .05), but the transcriptional expression in heart is higher than other tissues, and the copy number in muscles and fat of JX is higher than others breeds. Statistical analysis revealed that the GBP2 gene CNV1 and CNV2 were significantly associated with growth traits (P < .05). In conclusion, this research established the correlations between CNVs of GBP2 gene and growth traits in different cattle breeds, and our results suggested that the CNVs in GBP2 gene may be considered markers for the molecular breeding of Chinese beef cattle.

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