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Nonstructural protein 11 (nsp11) of porcine reproductive and respiratory syndrome virus (PRRSV) promotes PRRSV infection in MARC-145 cells

文献类型： 外文期刊

作者： Shi, Xibao 1 ; Zhang, Xiaozhuan 1 ; Chang, Yongzhe 2 ; Jiang, Bo 5 ; Deng, Ruiguang 2 ; Wang, Aiping 4 ; Zhang, Gaipin 1 ;

作者机构： 1.Henan Normal Univ, Coll Life Sci, Xinxiang 453007, Peoples R China

2.Henan Acad Agr Sci, Henan Prov Key Lab Anim Immunol, Minist Agr, Key Lab Anim Immunol, Zhengzhou 450002, Henan, Peoples R China

3.Henan Agr Univ, Coll Vet Med & Anim Sci, Zhengzhou 450002, Henan, Peoples R China

4.Zhengzhou Univ, Dept Bioengn, Zhengzhou 450002, Henan, Peoples R China

5.Chongqing Police Coll, Off Sci & Technol, Chongqing 401331, Peoples R China

关键词： PRRSV;Small interfering RNA;nsp11

期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.741； 五年影响因子：2.955 ）

ISSN： 1746-6148

年卷期： 2016 年 12 卷

页码：

收录情况： SCI

摘要： Background: Porcine reproductive and respiratory syndrome virus (PRRSV) induces one of most important devastating disease of swine worldwide, and the current methods poorly control it. Previous studies have indicated that the nonstructural protein 11 (nsp11) of PRRSV may be an important protein for the immune escape of PRRSV. Results: Here, we firstly explored the effect of over-expression of nsp11 on PRRSV infection and found that over-expression of nsp11 enhanced the PRRSV titers while the small interfering RNA (siRNAs) specifically targeting nsp11 could reduce the PRRSV titers in MARC-145 cells. Conclusion: In conclusion, PRRSV nsp11 promotes PRRSV infection in MARC-145 cells and siRNAs targeting nsp11 may be a potential therapeutic strategy to control PRRSV in future.

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[1]Small interfering RNA targeting nonstructural protein1 alpha (nsp1 alpha) of porcine reproductive and respiratory syndrome virus (PRRSV) can reduce the replication of PRRSV in MARC-145 cells. Shi, Xibao,Zhang, Xiaozhuan,Li, Chunxi,Shi, Xibao,Chang, Yongzhe,Zhang, Gaiping,Shi, Xibao,Chang, Yongzhe,Wang, Li,Chen, Jing,Wang, Chao,Deng, Ruiguang,Zhang, Gaiping,Zhang, Xiaozhuan,Jiang, Kai,Fan, Jianming.

[2]Endoribonuclease activities of porcine reproductive and respiratory syndrome virus nsp11 was essential for nsp11 to inhibit IFN-beta induction. Shi, Xibao,Wang, Li,Li, Xuewu,Zhang, Gaiping,Guo, Junqing,Zhao, Dong,Chai, Shujun,Deng, Ruiguang. 2011

[3]Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Inhibits RNA-Mediated Gene Silencing by Targeting Ago-2. Chen, Jing,Zhang, Gaiping,Chen, Jing,Shi, Xibao,Wang, Li,Luo, Jun,Xing, Guangxu,Deng, Ruiguang,Zhang, Gaiping,Shi, Xibao,Zhang, Xiaozhuan,Yang, Hong,Li, Jinting,Wang, Aiping,Zhang, Gaiping. 2015

[4]猪源Viperin蛋白抑制猪繁殖与呼吸综合征病毒感染MARC-145细胞. 方剑玉,白娟,郭小参,白献晓,朱文豪. 2017

[5]猪繁殖与呼吸综合征免疫学研究进展. 冯丽丽,张改平,乔松林,张丽萍. 2009

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[8]GP5 protein-based ELISA for the detection of PRRSV antibodies. Wang, Y.,Wang, Y.,Guo, J.,Qiao, S.,Li, Q.,Yang, J.,Jin, Q.,Zhang, G..

[9]MicroRNA 373 Facilitates the Replication of Porcine Reproductive and Respiratory Syndrome Virus by Its Negative Regulation of Type I Interferon Induction. Chen, Jing,Zhang, Gai-Ping,Shi, Xibao,Zhang, Xiaozhuan,Chen, Jing,Shi, Xibao,Wang, Li,Yang, Yanyan,Deng, Ruiguang,Zhang, Gai-Ping,Zhang, Gai-Ping,Wang, Aiping,Zhang, Gai-Ping,Zhang, Gai-Ping.

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[11]The Crystal Structure of the Fifth Scavenger Receptor Cysteine-Rich Domain of Porcine CD163 Reveals an Important Residue Involved in Porcine Reproductive and Respiratory Syndrome Virus Infection. Ma, Hongfang,Huang, Xiaojing,Zhang, Gai-Ping,Ma, Hongfang,Qiao, Songlin,Zhi, Yubao,Chen, Xin-Xin,Yang, Yanyan,Huang, Xiaojing,Li, Rui,Zhang, Gai-Ping,Jiang, Longguang,Huang, Mingdong.

[12]Molecular epidemiology of porcine reproductive and respiratory syndrome virus in Central China since 2014: The prevalence of NADC30-like PRRSVs. Wang, Lin-jian,Gu, Yu,Zhang, Gaiping,Wang, Lin-jian,Xie, Weitao,Chen, Xin-xin,Qiao, Songlin,Zhao, Mengmeng,Gu, Yu,Zhao, Bao-lei,Zhang, Gaiping,Zhao, Mengmeng,Zhao, Bao-lei,Zhang, Gaiping.

[13]Recombinant beta interferon could clear the low-dose infected porcine reproductive and respiratory syndrome virus (PRRSV) in MARC-145 cells. Shi, X.,Zhang, X.,Li, W.,Zhang, G.,Shi, X.,Wang, L.,Deng, R.,Zhang, G.,Jiang, B.,Wang, A..

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