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Endoribonuclease activities of porcine reproductive and respiratory syndrome virus nsp11 was essential for nsp11 to inhibit IFN-beta induction

文献类型： 外文期刊

作者： Shi, Xibao 1 ; Wang, Li 1 ; Li, Xuewu 1 ; Zhang, Gaiping 1 ; Guo, Junqing 1 ; Zhao, Dong 1 ; Chai, Shujun 1 ; Deng, Ruigu 1 ;

作者机构： 1.Henan Acad Agr Sci, Henan Prov Key Lab Anim Immunol, Zhengzhou 450002, Peoples R China

关键词： Porcine reproductive and respiratory syndrome virus (PRRSV);Interferon beta;nsp11;Endoribonuclease;IFN-regulatory factor 3

期刊名称：MOLECULAR IMMUNOLOGY （ 影响因子：4.407； 五年影响因子：4.227 ）

ISSN： 0161-5890

年卷期： 2011 年 48 卷 12-13 期

页码：

收录情况： SCI

摘要： Previous studies have shown that PRRSV nsp11 which was an endoribonuclease, was an interferon antagonist, however, the mechanism that nsp11 inhibited IFN-beta production was unclear. To explore whether the endoribonuclease was required for nsp11 to disrupt the IFN-beta production, substitutions of the presumed catalytic histidine and lysine residues of nsp11 were introduced into plasmid pcDNA 3.1-FLAG. The results showed that mutation that inactivated endoribonuclease made nsp11 lose its ability to inhibit Poly(I:C)-induced IFN-beta promoter activity. In conclusion, our present work indicated that the endoribonuclease activity of nsp11 was essential for nsp11 to inhibit the IFN-beta induction. (C) 2011 Elsevier Ltd. All rights reserved.

  • 相关文献

[1]Porcine reproductive and respiratory syndrome virus (PRRSV) could be sensed by professional beta interferon-producing system and had mechanisms to inhibit this action in MARC-145 cells. Shi, Xibao,Wang, Li,Zhi, Yubao,Xing, Guangxu,Zhao, Dong,Deng, Ruiguang,Zhang, Gaiping. 2010

[2]Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Inhibits RNA-Mediated Gene Silencing by Targeting Ago-2. Chen, Jing,Zhang, Gaiping,Chen, Jing,Shi, Xibao,Wang, Li,Luo, Jun,Xing, Guangxu,Deng, Ruiguang,Zhang, Gaiping,Shi, Xibao,Zhang, Xiaozhuan,Yang, Hong,Li, Jinting,Wang, Aiping,Zhang, Gaiping. 2015

[3]Nonstructural protein 11 (nsp11) of porcine reproductive and respiratory syndrome virus (PRRSV) promotes PRRSV infection in MARC-145 cells. Shi, Xibao,Zhang, Xiaozhuan,Shi, Xibao,Chang, Yongzhe,Deng, Ruiguang,Zhang, Gaiping,Zhang, Xiaozhuan,Zhang, Gaiping,Wang, Aiping,Jiang, Bo. 2016

[4]The prevalent status and genetic diversity of porcine reproductive and respiratory syndrome virus in China: a molecular epidemiological perspective. Guo, Zhenhua,Chen, Xin-xin,Li, Rui,Qiao, Songlin,Zhang, Gaiping,Zhang, Gaiping,Zhang, Gaiping. 2018

[5]Amino acid at position 176 was essential for porcine reproductive and respiratory syndrome virus (PRRSV) non-structural protein 1 alpha (nsp1 alpha) as an inhibitor to the induction of IFN-beta. Shi, Xibao,Chen, Jing,Xing, Guangxu,Zhang, Gaiping,Shi, Xibao,Chen, Jing,Xing, Guangxu,Hu, Xiaofei,Zhi, Yubao,Guo, Junqing,Wang, Li,Qiao, Songlin,Lu, Qingxia,Zhang, Gaiping,Zhang, Xiaozhuan.

[6]Antibody-dependent enhancement of PRRSV infection down-modulates TNF-alpha and IFN-beta transcription in macrophages. Bao, Dengke,Wan, Bo,Wang, Yinbiao,Zhang, Gaiping,Bao, Dengke,Wang, Rui,Qiao, Songlin,Wan, Bo,Wang, Yinbiao,Liu, Mingyang,Shi, Xibao,Guo, Juiqing,Zhang, Gaiping.

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