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Porcine reproductive and respiratory syndrome virus (PRRSV) could be sensed by professional beta interferon-producing system and had mechanisms to inhibit this action in MARC-145 cells

文献类型： 外文期刊

作者： Shi, Xibao 1 ; Wang, Li 1 ; Zhi, Yubao 1 ; Xing, Guangxu 1 ; Zhao, Dong 1 ; Deng, Ruiguang 1 ; Zhang, Gaiping 1 ;

作者机构： 1.Henan Acad Agr Sci, Henan Prov Key Lab Anim Immunol, Zhengzhou 450002, Peoples R China

关键词： Porcine reproductive and respiratory syndrome virus (PRRSV);Interferon beta;IFN-regulatory factor

期刊名称：VIRUS RESEARCH （ 影响因子：3.303； 五年影响因子：3.445 ）

ISSN： 0168-1702

年卷期： 2010 年 153 卷 1 期

页码：

收录情况： SCI

摘要： Porcine reproductive and respiratory syndrome virus (PRRSV) causes an economically important disease in swine-producing area, and interferon beta (IFN-beta) is the first responder against the animal virus infection. However, whether PRRSV could induce the production of IFN-beta is controversial. In this paper, we first time found that PRRSV could phosphorylate IFN-regulatory factor 3 (IRF-3) and weakly activate the IFN-beta promoter in MARC-145 cells in early infection, but the activations of IRF-3 and IFN-beta promoter were rapidly inhibited in the following infection. Furthermore, which components or products of the invading PRRSV cause PRRSV to inhibit IFN-beta promoter activity attracted our attentions. The obtained results showed that PRRSV nsp1 could inhibit Poly(I:C)-induced IFN-beta promoter activity in MARC-145 cells by down-regulating the protein level of IRF-3 and inhibiting the phosphorylation of IRF-3. In conclusion, our results suggested that PRRSV could be sensed by professional IFN-beta-producing system and had mechanisms to inhibit this action in MARC-145 cells. (C) 2010 Elsevier B.V. All rights reserved.

  • 相关文献

[1]Endoribonuclease activities of porcine reproductive and respiratory syndrome virus nsp11 was essential for nsp11 to inhibit IFN-beta induction. Shi, Xibao,Wang, Li,Li, Xuewu,Zhang, Gaiping,Guo, Junqing,Zhao, Dong,Chai, Shujun,Deng, Ruiguang. 2011

[2]Antibody-dependent enhancement of PRRSV infection down-modulates TNF-alpha and IFN-beta transcription in macrophages. Bao, Dengke,Wan, Bo,Wang, Yinbiao,Zhang, Gaiping,Bao, Dengke,Wang, Rui,Qiao, Songlin,Wan, Bo,Wang, Yinbiao,Liu, Mingyang,Shi, Xibao,Guo, Juiqing,Zhang, Gaiping.

[3]Amino acid at position 176 was essential for porcine reproductive and respiratory syndrome virus (PRRSV) non-structural protein 1 alpha (nsp1 alpha) as an inhibitor to the induction of IFN-beta. Shi, Xibao,Chen, Jing,Xing, Guangxu,Zhang, Gaiping,Shi, Xibao,Chen, Jing,Xing, Guangxu,Hu, Xiaofei,Zhi, Yubao,Guo, Junqing,Wang, Li,Qiao, Songlin,Lu, Qingxia,Zhang, Gaiping,Zhang, Xiaozhuan.

[4]Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Inhibits RNA-Mediated Gene Silencing by Targeting Ago-2. Chen, Jing,Zhang, Gaiping,Chen, Jing,Shi, Xibao,Wang, Li,Luo, Jun,Xing, Guangxu,Deng, Ruiguang,Zhang, Gaiping,Shi, Xibao,Zhang, Xiaozhuan,Yang, Hong,Li, Jinting,Wang, Aiping,Zhang, Gaiping. 2015

[5]The prevalent status and genetic diversity of porcine reproductive and respiratory syndrome virus in China: a molecular epidemiological perspective. Guo, Zhenhua,Chen, Xin-xin,Li, Rui,Qiao, Songlin,Zhang, Gaiping,Zhang, Gaiping,Zhang, Gaiping. 2018

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