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Isolation and molecular characterization of an H5N1 swine influenza virus in China in 2015

文献类型： 外文期刊

作者： Wu, Haibo 1 ; Yang, Fan 1 ; Lu, Rufeng 2 ; Xu, Lihua; Liu, Fumin 1 ; Peng, Xiuming 1 ; Wu, Nanping 1 ;

作者机构： 1.Zhejiang Univ, State Key Lab Diag & Treatment Infect Dis, Collaborat Innovat Ctr Diag & Treatment Infect Di, Affiliated Hosp 1,Sch Med, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China

2.Zhejiang Chinese Med Univ, Dept Emergency, A

关键词： Swine influenza virus;H5N1;Reassortment;Poultry;EASTERN China

期刊名称：ARCHIVES OF VIROLOGY （ 影响因子：2.574； 五年影响因子：2.466 ）

ISSN： 0304-8608

年卷期： 2018 年 163 卷 3 期

页码：

收录情况： SCI

摘要： In 2015, an H5N1 influenza virus was isolated from a pig in Zhejiang Province, Eastern China. This strain was characterized by whole-genome sequencing with subsequent phylogenetic analysis. Phylogenetic analysis showed that all segments from this strain belonged to clade 2.3.2 and that it had received its genes from poultry influenza viruses in China. A Glu627Lys mutation associated with pathogenicity was observed in the PB2 protein. This strain was moderately pathogenic in mice and was able to replicate without prior adaptation. These results suggest that active surveillance of swine influenza should be used as an early warning system for influenza outbreaks in mammals.

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