文献类型： 外文期刊

作者： Wang, Jingyu ¹ ; Yan, Zhirong ¹ ; Liu, Haoran ¹ ; Wang, Wenjie ³ ; Liu, Yakun ³ ; Zhu, Xu ⁶ ; Tian, Lili ⁷ ; Zhao, Jianjun ⁵ ; Peng, Qisheng ¹ ; Bi, Zhenwei ³ ;

作者机构： 1.Jilin Univ, Inst Zoonosis, Key Lab Zoonosis Res, State Key Lab Diag & Treatment Severe Zoonot Infec, Changchun 130062, Peoples R China

2.Jilin Univ, Coll Vet Med, Changchun 130062, Peoples R China

3.Jiangsu Acad Agr Sci, Inst Vet Med, Key Lab Vet Biol Engn & Technol, Minist Agr & Rural Affairs, Nanjing 210014, Jiangsu, Peoples R China

4.Jiangsu Agrianim Husb Vocat Coll, Sch Pet Sci & Technol, Taizhou 225300, Jiangsu, Peoples R China

5.Heilongjiang Bayi Agr Univ, Coll Anim Sci & Vet Med, Daqing, Heilongjiang, Peoples R China

6.Shanghai GlinX Biotechnol Co Ltd, Shanghai 200050, Peoples R China

7.Linyi Vocat Univ Sci & Technol, Dept Modern Agr, Linyi 276025, Shandong, Peoples R China

8.GuoTai Taizhou Ctr Technol Innovat Vet Biol, Taizhou 225300, Jiangsu, Peoples R China

期刊名称：TRANSBOUNDARY AND EMERGING DISEASES （ 影响因子：4.3； 五年影响因子：4.3 ）

ISSN： 1865-1674

年卷期： 2024 年 2024 卷

页码：

收录情况： SCI

摘要： Feline panleukopenia (FPL) is a highly contagious infectious disease caused by infection with feline parvovirus (FPV) and canine parvovirus type 2 (CPV-2). In recent years, the number of cats with FPL has increased with the expansion of pet cat population in China. The feces of 51 cats with diarrhea symptoms collected from 2021 to 2022 in Eastern Shandong, China, were detected by polymerase chain reaction for parvovirus and other viruses related to feline diarrhea to investigate the prevalence and gene variation of parvovirus in cats. In all the 51 samples, 45.1% (23/51) were positive for at least one viral pathogen, and the positivity of parvovirus was 41.2% (21/51), showing a high prevalence. Multiple-pathogen testing indicated high-coinfection rates of 42.9% (9/21) with other common viruses in parvovirus-positive cats. Most of the coinfections are feline coronavirus (FCoV), followed by feline astrovirus (FAstV) and feline bocavirus (FBoV). The complete VP2 sequences of 21 parvoviruses were obtained. Among them, 20 sequences were identified as FPV, and only one was CPV-2c of Asian origin, which was first detected from cats in Eastern Shandong, China. A phylogenetic tree of the 20 FPVs was constructed together with 698 FPVs (cat/dog host) worldwide on the basis of complete VP2. The 18 FPVs displayed high-sequence identity to one another (99.8%-100%), and they were clustered into FPV-G1 group, whereas the other two were clustered into FPV-G3 group. The FPV-G1 group increased dramatically to become predominant after 2019 in China, contributing to the prevalence of A91S mutation due to 96.07% FPV-G1 with A91S mutation as well as 100% of FPV-G2 and 99.12% of FPV-G3 with 91A in the statistical analysis. This study enriched the understanding of the prevalence, molecular evolution, and cross-species transmission of parvovirus in cats and provided a basis for responding to challenges in the diagnosis and treatment of FPL.