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Mitochondria-mediated Apoptosis in Human Lung Cancer A549 Cells by 4-Methylsulfinyl-3-butenyl Isothiocyanate from Radish Seeds

文献类型： 外文期刊

作者： Wang, Nan 1 ; Wang, Wei 2 ; Huo, Po 1 ; Liu, Cai-Qin 1 ; Jin, Jian-Chang 1 ; Shen, Lian-Qing 3 ;

作者机构： 1.Zhejiang Shuren Univ, Coll Biol & Environm Engn, Hangzhou, Zhejiang, Peoples R China

2.Zhejiang Acad Agr Sci, Inst Qual & Stand Agr Prod, Hangzhou, Zhejiang, Peoples R China

3.Zhejiang Gongshang Univ, Coll Food Sci & Biotechnol Engn, Hangzhou, Zhejiang, Peoples R China

关键词： 4-Methylsulfinyl-3-butenyl isothiocyanate;apoptosis;A549 cells;mitochondrial pathways

期刊名称：ASIAN PACIFIC JOURNAL OF CANCER PREVENTION （ 影响因子：2.514； 五年影响因子：2.267 ）

ISSN： 1513-7368

年卷期： 2014 年 15 卷 5 期

页码：

收录情况： SCI

摘要： 4-Methylsulfinyl-3-butenyl isothiocyanate (MTBITC) found in the radish (Raphanus sativus L.), is a well-known anticancer agent. In this study, the mechanisms of the MTBITC induction of cell apoptosis in human A549 lung cancer cells were investigated. Our PI staining results showed that MTBITC treatment significantly increased the apoptotic sub-G1 fraction in a dose-dependent manner. The mechanism of apoptosis induced by MTBITC was investigated by testing the change of mitochondrial membrane potential (Delta psi m), the expression of mRNAs of apoptosis-related genes by RT-PCR, and the activities of caspase-3 and -9 by caspase colorimetric assay. MTBITC treatment decreased mitochondrial membrane potential by down-regulating the rate of Bcl-2/Bax and Bcl-xL/Bax, and activation of caspase-3 and -9. Therefore, mitochondrial pathway and Bcl-2 gene family could be involved in the mechanisms of A549 cell apoptosis induced by MTBITC.

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