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Interactions Analysis in BSA-loaded Chitosan Nanoparticles at Different pH Values

文献类型: 外文期刊

作者: Liu, Yong 1 ; Sun, Yan 2 ; Li, Yanli 1 ; Xu, Shaochun 1 ; Xu, Yaoxing 1 ;

作者机构: 1.Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, 198 Shiqiao Rd, Hangzhou, Zhejiang, Peoples R China

2.Hangzhou Normal Univ, Hangzhou, Zhejiang, Peoples R China

关键词: Chitosan;Bovine Serum Albumin;Nanoparticles;Interaction

期刊名称:FRONTIER OF NANOSCIENCE AND TECHNOLOGY ( 影响因子:0.399; )

ISSN: 0255-5476

年卷期: 2011 年 694 卷

页码:

收录情况: SCI

摘要: In this paper, the properties of chitosan nanoparticles and bovine serum albumin-loaded chitosan nanoparticles prepared with sodium tripolyphosphate at different pH values were discussed. Interactions in chitosan nanoparticles and bovine serum albumin-loaded chitosan nanoparticles were analyzed by Fourier transform infrared spectroscopy and differential scanning calorimetry. The results indicated that there were more complicated interactions in chitosan nanoparticles prepared at different pH values. When the pH values were lower or higher than isoelectric point value of target protein (bovine serum albumin), the big different interactions occurred in chitosan nanoparticles. These differences also would result in different releasing properties.

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