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NAD(+)-dependent HDAC inhibitor stimulates Monascus pigment production but inhibit citrinin

文献类型： 外文期刊

作者： Hu, Yan 1 ; Zhou, Youxiang 2 ; Mao, Zejing 1 ; Li, Huihui 3 ; Chen, Fusheng 1 ; Shao, Yanchun 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Hubei, Peoples R China

2.Hubei Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Wuhan 430064, Hubei, Peoples R China

3.Wuhan Business Univ, Coll Cuisine & Food Technol, Wuhan 430056, Hubei, Peoples R China

关键词： Monascus ruber;Epigenetic modifier;Dihydrocoumarin;Secondary metabolites;Organism growth

期刊名称：AMB EXPRESS （ 影响因子：3.298； 五年影响因子：3.427 ）

ISSN： 2191-0855

年卷期： 2017 年 7 卷

页码：

收录情况： SCI

摘要： Monascus species are edible fungi due to the production of food colorant and other beneficial compounds. Hence, it has been an attractive thesis to improve their productivities. Increasing numbers of investigations revealed that regulating the activities of histone deacetylases can significantly perturb secondary metabolites (SM) production at a global level. In this study, dihydrocoumarin (DHC, an inhibitor of the Sirtuin family of NAD(+)- dependent deacetylases) was used to treat Monascus ruber for evaluating its effects on organism growth and SM production. The results revealed that the variation trends of colonial sizes, biomass and mycotoxin were in a dose-dependent manner. Generally, they decreased with the increased DHC concentrations in the designed range. But the variation trend of pigment was different. Comparison of SM profile, three new peaks occurred to the mycelia extractions from DHC-treated strain corresponding to molecular weights 402, 416 and 444, respectively. These three compounds were identified as Monasfluol B, Monascus azaphilone C and acetyl-monasfluol B (a new Monascus chemical pigment structure). In short, DHC can stimulate M. ruber strain to produce more pigment-like polyketides but inhibition of mycotoxin (citrinin).

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[1]mrskn7, a putative response regulator gene of Monascus ruber M7, is involved in oxidative stress response, development, and mycotoxin production. Shao, Yanchun,Chen, Fusheng,Yang, Sha,Zhang, Zhouwei,Zhou, Youxiang.

[2]Identification and role analysis of an intermediate produced by a polygenic mutant of Monascus pigments cluster in Monascus ruber M7. Liu, Jiao,Yi, Tao,Lei, Ming,Liu, Qingpei,Shao, Yanchun,Chen, Fusheng,Zhou, Youxiang,Zhao, Mingming,Chen, Fusheng,Xie, Nana.

[3]Inactivation of the global regulator LaeA in Monascus ruber results in a species-dependent response in sporulation and secondary metabolism. Shao, Yanchun,Li, Mu,Chen, Fusheng,Wang, Xiaohong,Chen, Fusheng,Liu, Qingpei,Cai, Li,Shao, Yanchun,Li, Mu,Wang, Xiaohong,Chen, Fusheng,Zhou, Youxiang.

[4]Effects of cyclic AMP on development and secondary metabolites of Monascus ruber M-7. Chen, F.,Chen, F.,Lai, Y.,Wang, L.,Qing, L.,Chen, F.. 2011

[5]Effects of an alternative oxidase gene on conidia viability under external stresses in Monascus ruber M7. Shao, Yanchun,Li, Qi,Chen, Fusheng,Zhou, Youxiang,Chen, Fusheng. 2017

[6]Identification of Mga1, a G-protein alpha-subunit gene involved in regulating citrinin and pigment production in Monascus ruber M7. Li, Li,Shao, Yanchun,Li, Qi,Yang, Sha,Chen, Fusheng,Shao, Yanchun,Chen, Fusheng,Chen, Fusheng. 2010

[7]Edible Filamentous Fungi from the Species Monascus: Early Traditional Fermentations, Modern Molecular Biology, and Future Genomics. Chen, Wanping,Li, Mu,Chen, Fusheng,Chen, Fusheng,Chen, Wanping,He, Yi,Shao, Yanchun,Li, Mu,Chen, Fusheng,Zhou, Youxiang,Feng, Yanli. 2015

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