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Promoter Characterization and Expression Pattern Analysis of Porcine TCAP Gene

文献类型： 外文期刊

作者： Qiao, Mu 1 ; Wu, Huayu 1 ; Huang, Jingshu 1 ; Peng, Xianwen 1 ; Liu, Guisheng 1 ; Feng, Zheng 1 ; Mei, Shuqi 1 ;

作者机构： 1.Hubei Acad Agr Sci, Inst Anim Husb & Vet, Hubei Key Lab Anim Embryo & Mol Breeding, Wuhan 430064, Peoples R China

关键词： Porcine;TCAP;promoter;bioinformatics;China

期刊名称：JOURNAL OF ANIMAL AND VETERINARY ADVANCES （ 影响因子：0.365； 五年影响因子：0.359 ）

ISSN： 1680-5593

年卷期： 2012 年 11 卷 11 期

页码：

收录情况： SCI

摘要： TCAP is one of the titin interacting Z-disc proteins involved in the regulation and development of normal sarcomeric structure. In this study, researchers cloned the 5 upstream region of porcine TCAP gene. Bioinformatic analysis of the 5' regulatory region has revealed that in addition to several ubiquitous transcription factors binding sites (SP1, AP1 and C/EBP) were found, several putative muscle-specific transcription factor binding sites (MyoD, MyoG and MEF2) were present in this region. Tissue expression analysis showed that the porcine TCAP gene was expressed abundantly in skeletal muscle. The study suggested that TCAP gene might be a prospective candidate gene affecting muscle mass and meat quality traits in the pig and would lay the groundwork for the further investigations on the regulation and physiological function of porcine TCAP gene.

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