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Identification of Mga1, a G-protein alpha-subunit gene involved in regulating citrinin and pigment production in Monascus ruber M7

文献类型： 外文期刊

作者： Li, Li 1 ; Shao, Yanchun 1 ; Li, Qi 1 ; Yang, Sha 1 ; Chen, Fusheng 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Hubei Province, Peoples R China

2.Huazhong Agr Univ, Natl Key Lab Agromicrobiol, Wuhan 430070, Hubei Province, Peoples R China

3.Huazhong Agr Univ, Minist Agr, Key Lab Food Safety Evaluat, Wuhan 430070, Hubei Province, Peoples R China

关键词： Monascus ruber;citrinin;pigment;G-protein alpha-subunit

期刊名称：FEMS MICROBIOLOGY LETTERS （ 影响因子：2.742； 五年影响因子：2.856 ）

ISSN： 0378-1097

年卷期： 2010 年 308 卷 2 期

页码：

收录情况： SCI

摘要： The filamentous fungi Monascus spp., which have been used in traditional fermented food in Asia for centuries, are well-known producers of a group of bioactive metabolites that are widely used as food additives and nutraceutical supplements worldwide. However, its potential to produce the mycotoxin citrinin poses a threat to food safety. Here, a G-protein alpha-subunit-encoding gene, Mga1 (Monascus G-protein alpha-subunit 1), which encodes a protein showing a high degree of identity to Group I alpha-subunits of fungal heterotrimeric G-proteins, was cloned from Monascus ruber M7. An Mga1-disrupted strain was obtained by homologous recombination. The disruptant produced approximately nine times more citrinin and 71% more pigments than the wild-type strain M7, indicating that the G-protein alpha-subunit encoded by Mga1 is involved in a signal transduction pathway regulating citrinin and pigment biosynthesis in M. ruber M7.

  • 相关文献

[1]mrskn7, a putative response regulator gene of Monascus ruber M7, is involved in oxidative stress response, development, and mycotoxin production. Shao, Yanchun,Chen, Fusheng,Yang, Sha,Zhang, Zhouwei,Zhou, Youxiang.

[2]mrflbA, encoding a putative FlbA, is involved in aerial hyphal development and secondary metabolite production in Monascus ruber M-7. Yang, Yishan,Li, Li,Li, Xin,Shao, Yanchun,Chen, Fusheng,Shao, Yanchun,Chen, Fusheng,Chen, Fusheng. 2012

[3]Identification and role analysis of an intermediate produced by a polygenic mutant of Monascus pigments cluster in Monascus ruber M7. Liu, Jiao,Yi, Tao,Lei, Ming,Liu, Qingpei,Shao, Yanchun,Chen, Fusheng,Zhou, Youxiang,Zhao, Mingming,Chen, Fusheng,Xie, Nana.

[4]Inactivation of the global regulator LaeA in Monascus ruber results in a species-dependent response in sporulation and secondary metabolism. Shao, Yanchun,Li, Mu,Chen, Fusheng,Wang, Xiaohong,Chen, Fusheng,Liu, Qingpei,Cai, Li,Shao, Yanchun,Li, Mu,Wang, Xiaohong,Chen, Fusheng,Zhou, Youxiang.

[5]Effects of cyclic AMP on development and secondary metabolites of Monascus ruber M-7. Chen, F.,Chen, F.,Lai, Y.,Wang, L.,Qing, L.,Chen, F.. 2011

[6]NAD(+)-dependent HDAC inhibitor stimulates Monascus pigment production but inhibit citrinin. Hu, Yan,Mao, Zejing,Chen, Fusheng,Shao, Yanchun,Zhou, Youxiang,Li, Huihui. 2017

[7]Effects of an alternative oxidase gene on conidia viability under external stresses in Monascus ruber M7. Shao, Yanchun,Li, Qi,Chen, Fusheng,Zhou, Youxiang,Chen, Fusheng. 2017

[8]Effects of glycerol on pigments and monacolin K production by the high-monacolin K-producing but citrinin-free strain, Monascus pilosus MS-1. Feng, Yanli,Shao, Yanchun,Chen, Fusheng,Feng, Yanli,Shao, Yanchun,Chen, Fusheng,Feng, Yanli,Zhou, Youxiang.

[9]A study of fluorescence properties of citrinin in beta-cyclodextrin aqueous solution and different solvents. Chen, Jianbiao,Dong, Lina,Lu, Liang,Chen, Fusheng,Wang, Xiaohong,Zhou, Youxiang,Hu, Dingjin,Chen, Fusheng,Wang, Xiaohong,Chen, Fusheng. 2012

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