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Cucurbitacins from fruits of Aquilaria sinensis

文献类型： 外文期刊

作者： Mei Wen-Li 1 ; Lin Feng 1 ; Zuo Wen-Jian 1 ; Wang Hui 1 ; Dai Hao-Fu 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China; Haikou Key Lab Res & Dev Trop Nat Prod, Haikou 571101, Peoples R China

关键词： Aquilaria sinensis;Chemical constituent;Cucurbitacin;Cytotoxic activity

期刊名称：CHINESE JOURNAL OF NATURAL MEDICINES （ 影响因子：3.0； 五年影响因子：2.869 ）

ISSN： 1672-3651

年卷期： 2012 年 10 卷 3 期

页码：

收录情况： SCI

摘要： AIM: To investigate the chemical constituents in the fruits of Aquilaria sinensis. METHODS: The chemical constituents were isolated by column chromatography on silica gel and Sephadex LH-20, and their structures were elucidated on the basis of spectroscopic analysis. RESULTS: Five compounds were isolated and identified as hexanorcucurbitacin (1), cucurbitacin I (2), cucurbitacin D (3), isocucurbitacin D (4), and neocucurbitacin B (5). CONCLUSION: Compounds 1-5 were reported from Aquilaria genus for the first time. Compounds 1, 2, 4, and 5 showed cytotoxic activities against K562, SGC-7901 and SMMC-7721.

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