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Antibacterial constituents from the endophytic fungus Penicillium sp of mangrove plant Cerbera manghas

文献类型： 外文期刊

作者： Han Zhuang 1 ; Mei Wen-Li 1 ; Cui Hai-Bin 1 ; Zeng Yan-Bo 1 ; Lin Hai-Peng 1 ; Hong Kui 1 ; Dai Hao-Fu 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

2.Shantou Univ, Inst Marine Sci, Shantou 515063, Peoples R China

关键词： mangrove plant;endophytic fungus;Penicillium sp.;antibacterial;chemical constituent

期刊名称：CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE （ 影响因子：0.65； 五年影响因子：0.481 ）

ISSN： 0251-0790

年卷期： 2008 年 29 卷 4 期

页码：

收录情况： SCI

摘要： To study the anti-bacterial constituents from endophytic fungus 093701 of mangrove plant Cerbera manghas, three compounds were isolated by column chromatography from the broth of endophytic fungus Penicillium sp. of Mangrove plant Cerbera manghas, and their structures were elucidated as 4-(3-hydroxybutan-2-yl)-3,6- dimethylbenzene-1,2-diol(1), 4-(3-hydroxybutan-2-yl)-3-acetyl-6-methylbenzene-1,2-diol(2), 3,4,5-trimethyl-1,2-benzenediol(3) by MS, NMR, H-1-H-1 COSY, HMQC, HMBC etc.. Among them, compounds 1 and 2 were new compounds, compound 3 was a new natural product. Bioassay results showed that compounds 1 and 3 possessed inhibitory effects on MRSA, while compound 2 had no anti-MRSA activity.

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