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Aromatic compounds from the halotolerant fungal strain of Wallemia sebi PXP-89 in a hypersaline medium

文献类型： 外文期刊

作者： Peng, Xiao-Ping 1 ; Wang, Yi 1 ; Liu, Pei-Pei 1 ; Hong, Kui 2 ; Chen, Hao 3 ; Yin, Xia 1 ; Zhu, Wei-Ming 1 ;

作者机构： 1.Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biol Sci & Biotechnol, Haikou 571101, Peoples R China

3.State Ocean Adm, Inst Oceanog 1, Qingdao 266061, Peoples R China

关键词： Halotolerant fungus;Wallemia sebi;Antibacterial activity;Cyclopentanopyridine alkaloid

期刊名称：ARCHIVES OF PHARMACAL RESEARCH （ 影响因子：4.946； 五年影响因子：3.483 ）

ISSN： 0253-6269

年卷期： 2011 年 34 卷 6 期

页码：

收录情况： SCI

摘要： A new cyclopentanopyridine alkaloid, 3-hydroxy-5-methyl-5,6-dihydro-7H-cyclopenta[b]pyridin-7-one (1), together with 11 known aromatic compounds were isolated from the secondary metabolites of the halotolerant fungal strain Wallemia sebi PXP-89 in 10% NaCl. Their structures including the absolute configurations of (2S,3S)-1-(4-hydroxyphenyl)butane-2,3-diol (2), (2R,3S)-1-(4-hydroxyphenyl)butane-2,3-diol (3), and (S)-3-hydroxy-4-(4-hydroxyphenyl)-2-one (4) were elucidated by spectroscopic analysis and a modified Mosher's method. Compound 1 exhibited antimicrobial activity against Enterobacter aerogenes with a MIC of 76.7 mu M. The absolute configurations of compounds 2-4 were determined for the first time.

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