Inhibitory effects of hinokitiol on tyrosinase activity and melanin biosynthesis and its antimicrobial activities
文献类型： 外文期刊
作者： Zhu, Yu-Jing 1 ; Qiu, Ling 2 ; Zhou, Jing-Jing 2 ; Guo, Hua-Yun 2 ; Hu, Yong-Hua 2 ; Li, Zhi-Cong 2 ; Wang, Qin 2 ; Chen, 1 ;
作者机构： 1.Fujian Acad Agr Sci, Agr Bioresource Res Inst, Fuzhou 350003, Peoples R China; Xiamen Univ, Sch Life Sci, Key Lab Minist Educ Cell Biol & Tumor Cell Engn, Xiamen, Peoples R China
2.Xiamen Univ, Key Lab Chem Biol Fujian Province, Xiamen, Peoples R China
关键词： Hinokitiol;tyrosinase;inhibition kinetics;melanin biosynthesis;antimicrobial activity
期刊名称：JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY （ 影响因子：5.051； 五年影响因子：4.598 ）
ISSN： 1475-6366
年卷期： 2010 年 25 卷 6 期
页码：
收录情况： SCI
摘要： The inhibitory effects of hinokitiol, a constituent of the woody oils isolated from Cupressaceae heartwood, on mushroom tyrosinase and melanin formation in B16 melanoma cells as well as its antimicrobial activity were investigated. Our results showed that hinokitiol could strongly inhibit both monophenolase activity and diphenolase activity of the enzyme and the inhibition was reversible. The IC(50) values were estimated as 9.67 mu M for monophenolase activity and 0.21 mu M for diphenolase activity. The lag time of the monophenolase activity was not obviously lengthened by the compound. Kinetic analyses showed that the inhibition mechanism of hinokitiol was a mixed-type inhibition of the diphenolase activity. Hinokitiol effectively inhibited both cellular tyrosinase activity and melanin biosynthesis in B16 melanoma cells with significant cytotoxicity. Furthermore, it was found that hinokitiol could inhibit the proliferation of Salmonella enteritidis, Escherichia coli, Bacillus subtilis, Staphyloccocus aureus, Klebsiella pneumoniae, and Ralstonia solanacearum to different extents. This research may widen the use of hinokitiol in the fields of food preservation, depigmentation, and insecticide use.
- 相关文献
作者其他论文 更多>>
-
Lipopeptides from Bacillus velezensis induced apoptosis-like cell death in the pathogenic fungus Fusarium concentricum
作者：Chen, Meichun;Deng, Yingjie;Xiao, Rongfeng;Liu, Bo;Wang, Jieping;Deng, Yingjie;Wang, Xun;He, Jin;Deng, Yingjie;Wang, Xun;He, Jin;Zheng, Meixia
关键词：crop protection; antifungal peptides; lipopeptides; pathogenic fungus; Fusarium concentricum; cell apoptosis
-
Accurate Prediction of Dissolved Oxygen in Perch Aquaculture Water by DE-GWO-SVR Hybrid Optimization Model
作者：Bao, Xingsheng;Wu, Renye;Jiang, Yilun;Qu, Fangfang;Zhang, Lintong;Chen, Linjie;Zhang, Wenqing;Xie, Lihang;Liu, Xinze;Qu, Fangfang;Liu, Bo
关键词：dissolved oxygen; water quality prediction; differential evolution; gray wolf optimizer
-
Structural Characteristic, Strong Antioxidant, and Anti-Gastric Cancer Investigations on an Oleoresin from Ginger (Zingiber officinale var. roscoe)
作者：Chen, Meichun;Lin, Enquan;Xiao, Rongfeng;Liu, Bo;Wang, Jieping;Li, Zuliang
关键词：ginger oleoresin; volatile components; phenolic compounds; antioxidant; cell proliferation and apoptosis
-
Lipopeptide C17 Fengycin B Exhibits a Novel Antifungal Mechanism by Triggering Metacaspase-Dependent Apoptosis in Fusarium oxysporum
作者：Deng, Ying-jie;Chen, Yan-ping;Wang, Jie-ping;Xiao, Rong-feng;Liu, Bo;Chen, Mei-chun;Deng, Ying-jie;Wang, Xun;He, Jin;Deng, Ying-jie;Wang, Xun;He, Jin;Chen, Zheng
关键词：Bacillus; lipopeptide; fengycin; pathogenic fungus; Fusarium oxysporum; cellapoptosis; metacaspase-dependent
-
Temporal dynamics of microbial composition and antibiotic resistome in fermentation bed culture pig farms across various ages
作者：Pan, Zhizhen;Wang, Weiyi;Chen, Jingyu;Avellan-Llaguno, Ricardo David;Xu, Wenjuan;Duan, Yifang;Huang, Qiansheng;Chen, Zheng;Liu, Bo;Chen, Jingyu;Wang, Weiyi
关键词：Fermentation bed culture; Microbial community; Antibiotic resistome; Bacterial pathogens; Metagenome-assembled genome
-
Testing a biocontrol agent consortium for suppression of tomato bacterial wilt through rhizosphere microecological regulation
作者：Zheng, Xuefang;Wang, Jieping;Chen, Meichun;Chen, Yanping;Chen, Zheng;Liu, Bo;Wang, Mingkuang
关键词：Bacterial wilt; Biocontrol control agent consortium; Microecological regulation; Ralstonia solanacearum; Rhizosphere
-
Engineering of Bacillus thuringiensis Cry2Ab toxin for improved insecticidal activity
作者：Xu, Lian;Zheng, Mei-Xia;Zhu, Yu-Jing;Fu, Bai-Wen;Shi, Yan
关键词：Cry2Ab; Protein engineering; Oligomerization; Pore-forming activity; Insecticidal activity
