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Mixture toxic effects of thiacloprid and cyproconazole on honey bees (Apis mellifera L.)

文献类型： 外文期刊

作者： Lv, Lu 1 ; Li, Wenhong 2 ; Li, Xinfang 1 ; Wang, Dou 1 ; Weng, Hongbiao 1 ; Zhu, Yu-Cheng 3 ; Wang, Yanhua 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Detect Pesticide Residues & Control Zhejia, Hangzhou 310021, Zhejiang, Peoples R China

2.Guizhou Acad Agr Sci, Guizhou Inst Plant Protect, Guiyang 550006, Guizhou, Peoples R China

3.United States Dept Agr, Agr Res Serv USDA ARS, 141 Expt Stn Rd, Stoneville, MS 38776 USA

关键词： Mixture effect; Bee toxicology; Biomarker; Synergetic toxicity

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：9.8； 五年影响因子：9.6 ）

ISSN： 0048-9697

年卷期： 2023 年 870 卷

页码：

收录情况： SCI

摘要： Pesticide exposure remains one of the main factors in the population decline of insect pollinators. It is urgently necessary to assess the effects of mixtures on pollinator risk assessments because they are often exposed to numerous agrochemicals. In the present study, we explored the mixture toxic effects of thiacloprid (THI) and cyproconazole (CYP) on honey bees (Apis mellifera L.). Our findings revealed that THI possessed higher acute toxicity to A. mellifera (96-h LC50 value of 216.3 mg a.i. L-1) than CYP (96-h LC50 value of 601.4 mg a.i. L-1). It's worth noting that the mixture of THI and CYP exerted an acute synergistic effect on honey bees. At the same time, the activities of detoxification enzyme cytochrome P450s (CYP450s) and neuro target enzyme Acetylcholinesterase (AChE), as well as the expressions of seven genes (CRBXase, CYP306A1, CYP6AS14, apidaecin, defensing-2, vtg, and gp-93) associated with detoxification metabolism, im -mune response, development, and endoplasmic reticulum stress, were significantly altered in the combined treatment compared with the corresponding individual exposures of THI or CYP. These data indicated that a mixture of THI and CYP could disturb the physiological homeostasis of honey bees. Our study provides a theoretical basis for in-depth studies on the impacts of pesticide mixtures on the health of honey bees. Our study also provides important guidance for the ra-tional application of pesticide mixtures to protect pollinators in agricultural production effectively.

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