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Isolation, identification and characteristics of Bibersteinia trehalosi from goat

文献类型： 外文期刊

作者： Guo, Rui 1 ; Xu, Mengen 3 ; Yang, Keli 1 ; Gao, Ting 1 ; Zhu, Jiajia 1 ; Liu, Wei 1 ; Yuan, Fangyan 1 ; Liu, Zewen 1 ; Li, Chang 1 ; Wu, Qiong 1 ; Nawaz, Shah 3 ; Zhou, Danna 1 ; Tian, Yongxiang 1 ;

作者机构： 1.Hubei Acad Agr Sci, Inst Anim Husb & Vet Sci, Key Lab Prevent & Control Agents Anim Bacteriosis, Minist Agr & Rural Affairs, Wuhan 430064, Peoples R China

2.Hubei Acad Agr Sci, Inst Anim Husb & Vet Sci, Hubei Prov Key Lab Anim Pathogen Microbiol, Wuhan 430064, Peoples R China

3.Huazhong Agr Univ, Coll Vet Med, Wuhan 430070, Peoples R China

4.Hubei Acad Agr Sci, Inst Anim Husb & Vet Sci, Wuhan 430064, Peoples R China

关键词： Bibersteinia trehalosi; Isolation; Whole-genome; Antibiogram; Pathogenicity

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.8； 五年影响因子：4.0 ）

ISSN： 0882-4010

年卷期： 2024 年 191 卷

页码：

收录情况： SCI

摘要： A conditionally pathogenic bacterium called Bibersteinia trehalosi inhabits the upper respiratory tract of ruminants and is becoming a significant cause of pneumonia, especially in goats. In this study, we identified a gramnegative bacteria strain isolated from dead goat 's lungs, which was named M01. By integrating the outcomes of its morphological and biochemical characterization with the investigation of the 16S rRNA gene sequence analysis, the isolate was identified as B. trehalosi . Based on antibiotic susceptibility tests, the isolate was shown to be resistant to beta-lactams, tetracyclines, and amphenicols. Its genome was discovered to comprise 2115 encoded genes and a circular chromosome measuring 2,345,568 bp using whole genome sequencing. Annotation of the VFBD database revealed that isolate M01 had four virulence genes encoding three virulence factors. The CARD database revealed that its genome has two antibiotic-resistance genes. Based on pathogenicity testing, isolate M01 was highly pathogenic to mice, primarily causing pneumonia, with an LD50 of 1.31 x 10 7 CFU/ml. Moreover, histopathology showed loss of alveolar structure and infiltration of lung inflammatory cells. Hence, the current study could provide sufficient information for prevention and control strategies for future epidemics of B. trehalosi in goat species.

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