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Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission

文献类型： 外文期刊

作者： Zhang, Hao 1 ; Zou, Chuangchao 1 ; Peng, Ouyang 1 ; Ashraf, Usama 2 ; Xu, Qiuping 3 ; Gong, Lang 1 ; Fan, Baochao 5 ; Zhang, Yun 1 ; Xu, Zhichao 1 ; Xue, Chunyi 1 ; Wei, Xiaona 1 ; Zhou, Qingfeng 6 ; Tian, Xiaoyan 6 ; Shen, Hanqin 6 ; Li, Bin 7 ; Zhang, Xiangbin 6 ; Cao, Yongchang 1 ;

作者机构： 1.Sun Yat sen Univ, Life Sci Sch, State Key Lab Biocontrol, Guangzhou, Peoples R China

2.Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan, Peoples R China

3.Sun Yat sen Univ, Sun Yat sen Mem Hosp, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou, Peoples R China

4.South China Agr Univ, Coll Vet Med, Key Lab Zoonosis Prevent & Control Guangdong Prov, Guangzhou, Peoples R China

5.Jiangsu Acad Agr Sci, Inst Vet Med, Key Lab Vet Biol Engn & Technol, Minist Agr, Nanjing, Peoples R China

6.Wens Foodstuff Grp Co Ltd, Guangdong Enterprise Key Lab Anim Hlth & Environm, Wens Grp Acad, Yunfu, Peoples R China

7.Yangzhou Univ, Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Peoples R China

8.South China Agr Univ, Coll Anim Sci, Guangzhou, Peoples R China

9.Stanford Univ, Dept Med, Div Infect Dis, Stanford, CA USA

关键词： coronavirus; porcine epidemic diarrhea virus; epidemiology; evolution; transmission

期刊名称：MOLECULAR BIOLOGY AND EVOLUTION （ 影响因子：10.7； 五年影响因子：15.1 ）

ISSN： 0737-4038

年卷期： 2023 年 40 卷 3 期

页码：

收录情况： SCI

摘要： With a possible origin from bats, the alphacoronavirus Porcine epidemic diarrhea virus (PEDV) causes significant hazards and widespread epidemics in the swine population. However, the ecology, evolution, and spread of PEDV are still unclear. Here, from 149,869 fecal and intestinal tissue samples of pigs collected in an 11-year survey, we identified PEDV as the most dominant virus in diarrheal animals. Global whole genomic and evolutionary analyses of 672 PEDV strains revealed the fast-evolving PEDV genotype 2 (G2) strains as the main epidemic viruses worldwide, which seems to correlate with the use of G2-targeting vaccines. The evolving pattern of the G2 viruses presents geographic bias as they evolve tachytely in South Korea but undergo the highest recombination in China. Therefore, we clustered six PEDV haplotypes in China, whereas South Korea held five haplotypes, including a unique haplotype G. In addition, an assessment of the spatiotemporal spread route of PEDV indicates Germany and Japan as the primary hubs for PEDV dissemination in Europe and Asia, respectively. Overall, our findings provide novel insights into the epidemiology, evolution, and transmission of PEDV, and thus may lay a foundation for the prevention and control of PEDV and other coronaviruses.

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