文献类型： 外文期刊
作者： Yang, Xin 1 ; Li, Zhenhui 1 ; Wang, Zhijun 1 ; Yu, Jiaao 1 ; Ma, Manting 1 ; Nie, Qinghua 2 ;
作者机构： 1.South China Agr Univ, Coll Anim Sci, State Key Lab Conservat & Utilizat Subtrop Agro B, Guangzhou 510642, Peoples R China
2.Minist Agr, Guangdong Prov Key Lab Agro Anim Genom & Mol Bree, Guangzhou 510642, Peoples R China
3.Minist Agr, Key Lab Chicken Genet Breeding & Reprod, Guangzhou 510642, Peoples R China
4.Natl Local Joint Engn Res Ctr Livestock Breeding, Guangzhou 510642, Peoples R China
关键词： microRNA; Cbl-b gene; mice; muscle atrophy
期刊名称：BIOMOLECULES （ 影响因子：6.064； 五年影响因子：6.191 ）
ISSN：
年卷期： 2022 年 12 卷 2 期
页码：
收录情况： SCI
摘要： As it is well known, muscle atrophy is a process in which protein degradation increases and protein synthesis decreases. This process is regulated by a variety of links. Among them, microRNAs play an essential role in this process, which has attracted widespread attention. In this paper, we find that miR-27b-3p and Cbl-b genes are significantly differentially expressed in the induced atrophy model. The dual-luciferase experiment and Western blot analysis confirmed that miR-27b-3p could regulate the expression of Cbl-b. In C2C12-differentiated myotubes, the overexpression of the Cbl-b gene showed that Cbl-b could upregulate the expression of MuRF-1 and Atrogin-1, which are related marker genes of muscle atrophy, at both the mRNA and protein levels, indicating that the Cbl-b gene can specifically affect muscle atrophy. The knockdown of the Cbl-b gene after C2C12-differentiated myotubes induced atrophy treatment can downregulate the expression of muscle-atrophy-related genes, indicating that manual intervention to downregulate the expression of Cbl-b has a certain alleviating effect on muscle atrophy. These data suggest that miR-27b-3p can regulate the expression of the Cbl-b gene and then exert a particular influence on muscle atrophy through the Cbl-b gene.
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