Thyroid disruption and growth inhibition of zebrafish embryos/larvae by phenanthrene treatment at environmentally relevant concentrations
文献类型： 外文期刊
作者： Wu, Luyin 1 ; Zhong, Liqiao 1 ; Ru, Huijun 1 ; Yao, Fan 1 ; Ni, Zhaohui 1 ; Li, Yunfeng 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Fishery Resources & Environm Sci Expt Stn Upper M, Minist Agr, Wuhan 430223, Peoples R China
2.Sun Yat Sen Univ, Guangdong Prov Engn Technol Res Ctr Environm Poll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Guangzhou 510080, Peoples R China
关键词： Phenanthrene; Thyroid disruption; Developmental toxicity; Growth inhibition
期刊名称：AQUATIC TOXICOLOGY （ 影响因子：5.202； 五年影响因子：5.758 ）
ISSN： 0166-445X
年卷期： 2022 年 243 卷
页码：
收录情况： SCI
摘要： Phenanthrene induces reproductive and developmental toxicity in fish, but whether it can disrupt the thyroid hormone balance and inhibit growth had not been determined to date. In this study, zebrafish embryos were exposed to phenanthrene (0, 0.1, 1, 10 and 100 mu g/L) for 7 days. The results of this experiment demonstrated that phenanthrene induced thyroid disruption and growth inhibition in zebrafish larvae. Phenanthrene significantly decreased the concentration of L-thyroxine (T4) but increased that of 3,5,3'-L-triiodothyronine (T3). The expression of genes related to the hypothalamic-pituitary-thyroid (HPT) axis was altered in zebrafish larvae exposed to phenanthrene. Moreover, phenanthrene exposure significantly increased the malformation rate and significantly reduced the survival rate and the body length of zebrafish larvae. Furthermore, phenanthrene significantly decreased the concentrations of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). Changes observed in gene expression patterns further support the hypothesis that these effects may be related to alterations along the GH/IGF-1 axis. In conclusion, our study indicated that exposure to phenanthrene at concentrations as low as 0.1 mu g/L resulted in thyroid disruption and growth inhibition in zebrafish larvae. Therefore, the estimation of phenanthrene levels in the aquatic environment needs to be revisited.
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