High spatial resolution mass spectrometry imaging for spatial metabolomics: Advances, challenges, and future perspectives
文献类型： 外文期刊
作者： Ma, Siyuan 1 ; Leng, Yixin 1 ; Li, Xiaoping 1 ; Meng, Yifan 1 ; Yin, Zhibin 1 ; Hang, Wei 1 ;
作者机构： 1.Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, MOE Key Lab Spectrochem Anal & Instrumentat, Xiamen 361005, Fujian, Peoples R China
2.Guangdong Acad Agr Sci, Agrobiol Gene Res Ctr, Guangdong Key Lab Crop Germplasm Resources Preserv, Guangzhou 510640, Guangdong, Peoples R China
关键词： Spatial metabolomics; Mass spectrometry imaging; High spatial resolution; Chemical imaging; Single -cell imaging
期刊名称：TRAC-TRENDS IN ANALYTICAL CHEMISTRY （ 影响因子：13.1； 五年影响因子：13.1 ）
ISSN： 0165-9936
年卷期： 2023 年 159 卷
页码：
收录情况： SCI
摘要： Spatial metabolomics is an emerging field of omics research that has enabled localizing small molecules in tissues and cells. Mass spectrometry imaging (MSI) technologies allow visualizing the spatial distri-bution of chemicals directly from biological samples without labeling and are becoming increasingly vocal for biological applications. Spatial metabolomics and its enabling technology, MSI, generate enormous visualization information that has extended the metabolomics information from point to plane and further motivates the development of MSI technology toward high spatial resolution and its application prospect in spatial metabolomics. Here, we highlight the latest advances in high spatial resolution MSI techniques for cellular and subcellular level imaging of metabolites and summarize the recent applications of spatial metabolomics based on high spatial resolution MSI for identification, quantitation, localization, and metabolic pathways of endogenous and exogenous compounds in tissues and single cells. We also prospect high spatial resolution MSI challenges based on the requirement for spatial metabolomics. This review is intended to provide readers with the latest progress of high spatial resolution MSI techniques and applications in spatial metabolomics, and discusses the potential challenges. (c) 2022 Elsevier B.V. All rights reserved.
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