Metabolomics and mass spectrometry imaging reveal the chronic toxicity of indoxacarb to adult zebrafish (Danio rerio) livers
文献类型： 外文期刊
作者： Ma, Lianlian 1 ; Yin, Zhibin 3 ; Xie, Qingrong 1 ; Xu, Yizhu 1 ; Chen, Yingying 1 ; Huang, Yudi 1 ; Li, Zhen 1 ; Zhu, Xinhai 5 ; Zhao, Yuhui 1 ; Wen, Wenlin 1 ; Xu, Hanhong 1 ; Wu, Xinzhou 1 ;
作者机构： 1.South China Agr Univ, Natl Key Lab Green Pesticide, Guangzhou 510642, Peoples R China
2.South China Agr Univ, Key Lab Nat Pesticide & Chem Biol, Minist Educ, Guangzhou 510642, Peoples R China
3.Guangdong Acad Agr Sci, Agro Biol Gene Res Ctr, Guangzhou 510640, Peoples R China
4.South China Agr Univ, Coll Plant Protect, Key Lab Bio Pesticide Creat & Applicat Guangdong P, Guangzhou 510642, Peoples R China
5.Sun Yat Sen Univ, Instrumental Anal & Res Ctr, Guangzhou 510275, Peoples R China
关键词： Zebrafish; Mass spectrometry imaging; Metabolomics; Indoxacarb; Toxicity mechanism
期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：13.6； 五年影响因子：12.7 ）
ISSN： 0304-3894
年卷期： 2023 年 453 卷
页码：
收录情况： SCI
摘要： Indoxacarb is a widely used insecticide in the prevention and control of agricultural pests, whereas its negative effects on non-target organisms remain largely unclear. Herein, we demonstrated the integrated metabolomics and mass spectrometry imaging (MSI) methods to investigate the chronic exposure toxicity of indoxacarb at environmentally relevant concentrations in adult zebrafish (Danio rerio) liver. Results showed that movement behaviors of zebrafish can be affected and catalase (CAT), glutamic oxalacetic transaminase (GOT), and glutamic pyruvic transaminase (GPT) activities were significantly increased after indoxacarb exposure for 28 days. Pathological analysis of zebrafish livers also showed that cavitation and pathological reactions occur. Metab-olomics results indicated that metabolic pathways of zebrafish liver could be significantly affected by indoxacarb, such as tricarboxylic acid (TCA) cycle and various amino acid metabolisms. MSI results revealed the spatial differentiation of crucial metabolites involved in these metabolic pathways within zebrafish liver. Taken together, these integrated MSI and metabolomics results revealed that the toxicity of indoxacarb arises from metabolic pathways disturbance, which resulted in the decrease of liver detoxification ability. These findings will promote the current understanding of pesticide risks and metabolic disorders in zebrafish liver, which provide new insights into the environmental risk assessment of insecticides on aquatic organisms.
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