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Identification and Genome Characterization of a Novel Muscovy Duck-Origin Goose Parvovirus with Three Recombinant Regions between Muscovy Duck Parvovirus and Goose Parvovirus

文献类型： 外文期刊

作者： Liu, Hongwei 1 ; Xu, Zhuoran 1 ; Wang, Shao 1 ; Cheng, Xiaoxia 1 ; Xiao, Shifeng 1 ; Zhu, Xiaoli 1 ; Zheng, Min 1 ; Lin, Fengqiang 1 ; Dong, Hui 1 ; Jiang, Dandan 1 ; Chen, Shaoying 1 ; Chen, Shilong 1 ;

作者机构： 1.Fujian Acad Agr Sci, Inst Anim Husb & Vet Med, Fuzhou 350003, Peoples R China

2.Fujian Agr & Forestry Univ, Coll Anim Sci, Fuzhou 350002, Peoples R China

3.Fujian Anim Dis Control Technol Dev Ctr, Fuzhou 350003, Peoples R China

期刊名称：TRANSBOUNDARY AND EMERGING DISEASES （ 影响因子：4.3； 五年影响因子：4.3 ）

ISSN： 1865-1674

年卷期： 2024 年 2024 卷

页码：

收录情况： SCI

摘要： Muscovy duck-origin goose parvovirus (MDGPV) is a new virus resulting from the natural recombination of Muscovy duck parvovirus (MDPV) and goose parvovirus (GPV). Previously identified MDGPV strains were found to have two recombination regions, one in the P9 promoter to the NS region and one in the VP3 gene, or only one recombination in the VP3 gene. In 2022, a novel strain of MDGPV known as 2022FZ was identified from China's mainland. Complete genome sequence analysis showed that there were three recombination regions in this strain: one located in the P9 promoter-NS (425-612 nt) region, one in the NS2 (1,483-1,824 nt) region, and one in the VP3 (3,124-4,248 nt) region, respectively. The recombination regions in the P9 promoter-NS, NS2, and VP3 genes were substituted with the relevant GPVs sequences, whereas the MDPV virulent strain served as the skeleton in this instance. In addition, the 2022FZ strain had multiple unique aa mutations in the NS protein and the VP protein. The Muscovy duckling challenge test showed that MDGPV-2022FZ is less pathogenic to Muscovy ducklings than two recombinant or sole recombinant MDGPV strains. For the first time, our study identified a three-region recombinant MDGPV strain and detected the novel recombination event in the NS2 gene. These results contribute to our understanding of the pathogenicity and genetic diversity of duck parvovirus.

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