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Growth hormone receptor gene influences mitochondrial function and chicken lipid metabolism by AMPK-PGC1 alpha-PPAR signaling pathway

文献类型： 外文期刊

作者： Yang, Minmin 1 ; Hu, Bowen 1 ; Sun, Donglei 4 ; Zhao, Changbin 1 ; Wei, Haohui 1 ; Li, Dajian 1 ; Liang, Zhiying 1 ; Zhao, Yongxia 1 ; Liang, Jinping 1 ; Shi, Meiqing 4 ; Luo, Qingbin 1 ; Nie, Qinghua 1 ; Zhang, Xiquan 1 ; Zhang, Dexiang 1 ; Li, Hongmei 1 ;

作者机构： 1.South China Agr Univ, Coll Anim Sci, State Key Lab Conservat & Utilizat Subtrop Agrobi, Guangzhou 510642, Guangdong, Peoples R China

2.Minist Agr, Guangdong Prov Key Lab AgroAnim Genom & Mol Breed, Guangzhou 510642, Guangdong, Peoples R China

3.Minist Agr, Key Lab Chicken Genet Breeding & Reprod, Guangzhou 510642, Guangdong, Peoples R China

4.Univ Maryland, Virginia Maryland Reg Coll Vet Med, Div Immunol, College Pk, MD USA

关键词： GHR; Lipid metabolism; Mitochondrial function; Pre-adipocyte differentiation; Sex-linked dwarf chickens

期刊名称：BMC GENOMICS （ 影响因子：4.547； 五年影响因子：4.931 ）

ISSN： 1471-2164

年卷期： 2022 年 23 卷 1 期

页码：

收录情况： SCI

摘要： Background Adipose tissue is an important endocrine and energy-storage organ in organisms, and it plays a crucial role in the energy-metabolism balance. Previous studies have found that sex-linked dwarf (SLD) chickens generally have excessively high abdominal fat deposition during the growing period, which increases feeding costs. However, the underlying mechanism of this fat deposition during the growth of SLD chickens remains unknown. Results The Oil Red O staining showed that the lipid-droplet area of SLD chickens was larger than that of normal chickens in E15 and 14d. Consistently, TG content in the livers of SLD chickens was higher than that of normal chickens in E15 and 14d. Further, lower Delta psi m and lower ATP levels and higher MDA levels were observed in SLD chickens than normal chickens in both E15 and 14d. We also found that overexpression of GHR reduced the expression of genes related to lipid metabolism (AMPK, PGC1 alpha, PPAR gamma, FAS, C/EBP) and oxidative phosphorylation (CYTB, CYTC, COX1, ATP), as well as reducing Delta psi m and ATP levels and increasing MDA levels. In addition, overexpression of GHR inhibited fat deposition in CPPAs, as measured by Oil Red O staining. On the contrary, knockdown of GHR had the opposite effects in vitro. Conclusions In summary, we demonstrate that GHR promotes mitochondrial function and inhibits lipid peroxidation as well as fat deposition in vivo and in vitro. Therefore, GHR is essential for maintaining the stability of lipid metabolism and regulating mitochondrial function in chicken.

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