Marine peptides as potential anti-aging agents: Preparation, characterization, mechanisms of action, and future perspectives
文献类型： 外文期刊
作者： Yao, Wanzi 1 ; Zhang, Yifeng 1 ; Zhang, Gaiping 1 ;
作者机构： 1.Peking Univ, Sch Adv Agr Sci, Dept Food Safety & Hlth, Beijing 100871, Peoples R China
2.Henan Acad Agr Sci, Key Lab Anim Immunol, Zhengzhou 450002, Peoples R China
3.Henan Agr Univ, Coll Vet Med, Int Joint Res Ctr Natl Anim Immunol, Zhengzhou 450046, Peoples R China
4.Zhengzhou Univ, Sch Life Sci, Zhengzhou 450001, Peoples R China
5.Longhu Lab Adv Immunol, Zhengzhou 450046, Peoples R China
关键词： Marine peptides; Anti-aging; Preparation; Mechanisms; Oxidative stress; Signaling pathways
期刊名称：FOOD CHEMISTRY （ 影响因子：8.5； 五年影响因子：8.2 ）
ISSN： 0308-8146
年卷期： 2024 年 460 卷
页码：
收录情况： SCI
摘要： Aging is a universal biological process characterized by a decline in physiological functions, leading to increased susceptibility to diseases. With global aging trends, understanding and mitigating the aging process is paramount. Recent studies highlight marine peptides as promising bioactive substances with potential anti-aging properties. This review critically examines the potential of marine peptides as novel food ingredients in antiaging, exploring their sources, preparation methods, physicochemical properties, and the underlying mechanisms through which they impact the aging process. Marine peptides exhibit significant potential in targeting aging, extending lifespan, and enhancing healthspan. They act through mechanisms such as reducing oxidative stress and inflammation, modulating mitochondrial dysfunction, inducing autophagy, maintaining extracellular matrix homeostasis, and regulating longevity-related pathways. Despite challenges in stability, bioavailability, and scalability, marine peptides offer significant potential in health, nutraceuticals, and pharmaceuticals, warranting further research and development in anti-aging.
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