Bioinspired metal-organic frameworks mediated efficient delivery of siRNA for cancer therapy
文献类型： 外文期刊
作者： Zhang, Yanfen 1 ; Yang, Langyu 1 ; Wang, Hao 1 ; Huang, Jionghua 1 ; Lin, Yinshan 1 ; Chen, Sheng 1 ; Guan, Xiaoling 1 ; Yi, Mengmeng 4 ; Li, Songpei 1 ; Zhang, Lingmin 1 ;
作者机构： 1.Guangzhou Med Univ, Third & Fifth Affiliated Hosp, Key Lab Mol Target & Clin Pharmacol, Sch Pharmaceut Sci, Guangzhou 511436, Peoples R China
2.Guangzhou Med Univ, Third & Fifth Affiliated Hosp, State & NMPA Key Lab Resp Dis, Sch Pharmaceut Sci, Guangzhou 511436, Peoples R China
3.Sixth Affiliated Hosp Guangzhou Med Univ, Qingyuan Peoples Hosp, Dept Oncol, Qingyuan 511518, Guangdong, Peoples R China
4.Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Beijing, Peoples R China
关键词： Metal-organic frameworks; PLK1; Small interfering RNA; Homotypic targeting; Cancer therapy
期刊名称：CHEMICAL ENGINEERING JOURNAL （ 影响因子：16.744； 五年影响因子：14.61 ）
ISSN： 1385-8947
年卷期： 2021 年 426 卷
页码：
收录情况： SCI
摘要： Small interfering RNA (siRNA) has emerged as a powerful tool in gene therapy to suppress gene expression. However, the fragile properties of siRNA and the low efficiency with non-specific gene delivery systems compromised the therapeutic effect of siRNA. Metal-organic frameworks (MOFs) are hybrid materials constructed by organic bridging ligands and metal cations with extremely high binding affinity with nuclei acids. But the properties of MOF-based nanoparticles, such as short circulation lifetime or non-specificity, hindered its application for cancer therapy. Herein, we fabricated a cancer cell membrane camouflaged zeolitic imidazolate framework 8 (ZIF-8)-based metal-organic frameworks (CAMEL) nanoparticles for targeted delivery of siRNA to knockdown Plk1 gene in tumors. ZIF-8 had high loading efficiency of siRNA, and the MOF-based nucleic acids complexes could be prepared at an adult dose once conveniently, which was not reported yet. MOF facilitated the release of siRNA from lysosomes. Cell membrane coating achieves targeted delivery of siRNA to tumor tissue and subsequent PLK1 silencing for tumor suppression. Our work developed a novel MOF-based nucleic acid delivery system for precise cancer therapy.
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