文献类型： 外文期刊
作者： Zheng, Kaizhi 1 ; Guo, Liangyong 2 ; Ullah, Saif 3 ; Cao, Yang 1 ; Huang, Xin 1 ; Shan, Huili 1 ; Jiang, Junfang 1 ; Wu, Jianliang 1 ; Jiang, Yongqing 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Anim Husb & Vet, Hangzhou, Peoples R China
2.Huzhou Acad Agr Sci, Huzhou, Peoples R China
3.Lasbela Univ Agr Water & Marine Sci, Fac Vet & Anim Sci, Lasbela, Pakistan
关键词： proteome; sheep; rumen; epithelium; postnatal development
期刊名称：FRONTIERS IN GENETICS （ 影响因子：3.7； 五年影响因子：4.3 ）
ISSN：
年卷期： 2022 年 13 卷
页码：
收录情况： SCI
摘要： Background: The development of the rumen epithelium is a critical physiological challenge for sheep. However, the molecular mechanism underlying postnatal rumen development in sheep remains rarely understood. Results: Here, we used a shotgun approach and bioinformatics analyses to investigate and compare proteomic profiles of sheep rumen epithelium tissue on day 0, 15, 30, 45, and 60 of age. A total of 4,523 proteins were identified, in which we found 852, 342, 164, and 95 differentially expressed proteins (DEPs) between day 0 and day 15, between day 15 and day 30, between day 30 and day 45, between day 45 and day 60, respectively. Furthermore, subcellular localization analysis showed that the DEPs were majorly localized in mitochondrion between day 0 and day 15, after which nucleus proteins were the most DEPs. Finally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses showed that DEPs significantly enriched in mitochondrion, ubiquitination, histone modifications, glutathione synthase activity, and wnt and nortch signaling pathways. Conclusion: Our data indicate that the biogenesis of mitochondrion in rumen epithelial cell is essential for the initiation of rumen epithelial development. Glutathione, wnt signaling pathway and nortch signaling pathway participated in rumen epithelial growth. Ubiquitination, post-translational modifications of histone might be key molecular functions in regulating rumen epithelial development.
- 相关文献
作者其他论文 更多>>
-
Dried tea residue can alter the blood metabolism and the composition and functionality of the intestinal microbiota in Hu sheep
作者：Guo, Liangyong;Shi, Xingyun;Liu, Liping;Yu, Shiqiang;Cao, Fang;Zheng, Kaizhi;Li, Manman;Peng, Zhenying
关键词：dried tea residue; Hu sheep; serum; immune; antioxidant; intestinal microorganisms
-
Proteome changes of dairy calves rumen epithelium from birth to postweaning
作者：Zheng, Kaizhi;Wu, Jianliang;Cao, Yang;Jiang, Yongqing;Huang, Xin;Jiang, Junfang;Ullah, Saif
关键词：proteome; dairy calves; rumen; epithelium; postnatal development
-
Proteomic and parallel reaction monitoring approaches to evaluate biomarkers of mutton tenderness
作者：Zheng, Kaizhi;Cao, Yang;Jiang, Junfang;Huang, Xin;Jiang, Yongqing;Wu, Jianliang;Yin, Yuyang;Guo, Liangyong;Li, Peng
关键词：Proteomics; PRM; Intensive fattening; Mutton; Tenderness; Biomarker
-
Transcript variants of long-chain acyl-CoA synthase 1 have distinct roles in sheep lipid metabolism
作者：Cao, Yang;Yu, Yongsheng;Zhang, Lichun;Liu, Yu;Jin, Haiguo;Liu, Lixiang;Cao, Yang;Zheng, Kaizhi;Wang, Sutian
关键词：ACSL1; transcript variants; sheep; APA; lipid metabolism
-
Genetic architecture of protein expression and its regulation in the mouse brain
作者：Erickson, Alyssa;Li, Ling;Even, Zachary;Huang, He;Wang, Xusheng;Zhou, Suiping;Peng, Junmin;Luo, Jie;Huang, Xin;Xu, Hai-Ming;Lu, Lu
关键词：Proteome; Mouse; Brain; Protein expression; Allele-specific expression; Protein regulation; Mass spectrometry
-
The involvement of translationally controlled tumor protein during lamb rumen epithelium development
作者：Zheng, Kaizhi;Wu, Jianliang;Cao, Yang;Jiang, Junfang;Huang, Xin;Jiang, Yongqing;Guo, Liangyong;Ying, Yingyu;Li, Peng;Meng, Chunhua
关键词：Translationally controlled tumor protein; Lamb; Rumen epithelia development; Acetate:propionate ratio
-
Effect of the ACAA1 Gene on Preadipocyte Differentiation in Sheep
作者：Wang, Yanli;Li, Xin;Xiao, Cheng;Liu, Yu;Jin, Haiguo;Cao, Yang;Cao, Yang
关键词：ACAA1 gene; preadipocyte differentiation; sheep; lipid metabolism; adipogenesis
