文献类型： 会议论文

第一作者： Eunbi Cho

作者： Eunbi Cho ¹ ; Kiyul Park ¹ ; Wongi Yeon ¹ ; Heejun Park ¹ ; Sung-Joo Hwang ¹ ;

作者机构： 1.Center for Nanotechnology-based New Drug Dosage Form, College of Pharmacy, Chungnam National University, 220Gung-dong, Yuseong-gu, Daejeon, 305-764, Korea

会议名称： Annual meeting & exposition of the Controlled Release Society

主办单位：

页码： 414-415

摘要： Microcrystal particles of Megestrol acetate(MA) were prepared using antisolvent precipitation technique that a simple method for reduction of particle sizes. Prepared microcrystal particles had an average size of 607.2-1984.4 nm with narrow size distribution, whereas the raw MAhad a particle size of several tens /Jin with wide sizedistribution. DSC, XPRD patterns and FT-IR spectra showed changes of crystallinity, morphology (crystal habit). In the dissolution tests, the processed MA showed enhanced dissolution properties when compared to the raw MA owing to a decreased particle size and an increased specific surface area.

分类号： n94