1Cannabidiol protects against Alzheimer's disease in C. elegans via ROS scavenging activity of its phenolic hydroxyl groups

作者： Zhang, Yue; Zhao, Lihui; Li, Hongyuan; Wang, Xiaohui; Jin, Sha; Lu, Yuyuan; Peng, Yinghua; Wang, Xiaohui; Wang, Xiaohui; SCI

机构： Changchun Univ Sci & Technol, Coll Life Sci & Technol, Changchun 130012, Jilin, Peoples R China; Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China; Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China; Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, State Key Lab Mol Biol Special Econ Anim, Changchun 130112, Jilin, Peoples R China; Univ Sci & Technol China, Dept Appl Chem & Engn, Hefei 230026, Anhui, Peoples R China; Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China;

来源：EUROPEAN JOURNAL OF PHARMACOLOGY

关键词： Cannabidiol; Reactive oxygen species; C; elegans; Alzheimer's disease

年份：2022

2ACT001 Inhibits TLR4 Signaling by Targeting Co-Receptor MD2 and Attenuates Neuropathic Pain

作者： Zhang, Tianshu; Lin, Cong; Wu, Siru; Wang, Xiaohui; Zhang, Tianshu; Lin, Cong; Wu, Siru; Wang, Xiaohui; Zhang, Tianshu; Wang, Xiaohui; Jin, Sha; Li, Xiaodong; Peng, Yinghua; Wang, Xiaohui; SCI

机构： Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun, Peoples R China; Univ Sci & Technol China, Sch Appl Chem & Engn, Hefei, Peoples R China; Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China; Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun, Peoples R China; Beijing Changping Huayou Hosp, Beijing, Peoples R China; Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, Changchun, Peoples R China; Beijing Natl Lab Mol Sci, Beijing, Peoples R China;

来源：FRONTIERS IN IMMUNOLOGY

关键词： neuropathic pain; toll-like receptor 4; myeloid differentiation protein 2; chronic constriction injury; ACT001

年份：2022

3Velvet antler methanol extracts (MEs) protects against oxidative stress in Caenorhabditis elegans by SKN-1

作者： Wang, Xue; Wu, Hua; Liu, Renjie; Wang, Xue; Wang, Xiaohui; Li, Hongyuan; Wang, Hongshuang; Wang, Xiaohui; Liu, Ying; Chang, Shuzhuo; Peng, Yinghua; Jin, Sha; Lu, Yuyuan; Guo, Zhijun; Guo, Zhijun; Wang, Xiaohui; SCI

机构： Jilin Agr Univ, Dept Food Sci & Engn, Changchun 130118, Jilin, Peoples R China; China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China; Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China; Chinese Acad Agr Sci, Key Lab Special Anim Mol Biol Jilin Prov, Specialty Res Inst, Changchun 130112, Jilin, Peoples R China; Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China; Qingdao Univ Sci & Technol, Coll Marine Sci & Biol Engn, Qingdao 266042, Shandong, Peoples R China; Yanbian Univ, Coll Agr, Yanji 133002, Peoples R China; Univ Sci & Technol China, Dept Appl Chem & Engn, Hefei 230026, Anhui, Peoples R China;

来源：BIOMEDICINE & PHARMACOTHERAPY

关键词： Velvet antler; Reactive oxygen species; Oxidative stress; Caenorhabditis elegans

年份：2020

4Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain

作者： Peng, Yinghua; Peng, Yinghua; Wang, Xiaohui; Zhang, Xiaozheng; Zhang, Tianshu; Li, Hongyuan; Wang, Yibo; Li, Hang; Chen, Hongqian; Wang, Xiaohui; Grace, Peter M.; Watkins, Linda R.; Grace, Peter M.; Watkins, Linda R.; Hutchinson, Mark R.; Hutchinson, Mark R.; Yin, Hang; Wang, Xiaohui; SCI

机构： Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, State Key Lab Mol Biol Special Econ Anim, Changchun 130112, Jilin, Peoples R China; Yantai Univ, Minist Educ, Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China; Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China; Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA; Univ Colorado, Ctr Neurosci, Boulder, CO 80309 USA; Univ Adelaide, Adelaide Med Sch, Discipline Physiol, Adelaide, SA, Australia; Univ Adelaide, ARC Ctr Excellence Nanoscale Biophoton, Adelaide, SA 5000, Australia; Tsinghua Univ, Tsinghua Univ Peking Univ Joint Ctr Life Sci, Sch Pharmaceut Sci, Beijing 100082, Peoples R China; Univ Sci & Technol China, Dept Appl Chem & Engn, Hefei 230026, Anhui, Peoples R China;

来源：BRAIN BEHAVIOR AND IMMUNITY

关键词： Toll-like receptor 4; Myeloid differentiation protein 2; Rats; Microglia; NFkB; Proinflammatory cytokines; CD11b; Allodynia

年份：2019

5Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling

作者： Zhang, Xiaozheng; Wang, Yibo; Zhang, Tianshu; Wu, Siru; Wang, Xiaohui; Zhang, Xiaozheng; Wang, Yibo; Zhang, Tianshu; Wu, Siru; Wang, Xiaohui; Zhang, Xiaozheng; Wang, Xiaohui; Peng, Yinghua; Grace, Peter M.; Kwilasz, Andrew J.; Watkins, Linda R.; Metcalf, Matthew D.; Portoghese, Philip S.; Selfridge, Brandon R.; Rice, Kenner C.; Selfridge, Brandon R.; Rice, Kenner C.; Hutchinson, Mark R.; Hutchinson, Mark R.; Wang, Xiaohui; SCI

机构： Chinese Acad Sci, Changchun Inst Appl Chem, Biol Chem Lab, Changchun, Jilin, Peoples R China; Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing, Jiangsu, Peoples R China; Univ Chinese Acad Sci, Beijing, Peoples R China; Chinese Acad Agr Sci, Inst Special Wild Econ Anim & Plants, State Key Lab Mol Biol Special Econ Anim, Changchun, Jilin, Peoples R China; Univ Colorado Boulder, Dept Psychol & Neurosci, Ctr Neurosci, Boulder, CO USA; Univ Minnesota, Coll Pharm, Dept Med Chem, Minneapolis, MN 55455 USA; NIDA, Drug Design & Synth Sect, Bethesda, MD 20892 USA; NIAAA, Bethesda, MD USA; Univ Adelaide, Discipline Physiol, Adelaide Med Sch, Adelaide, SA, Australia; Univ Adelaide, Australian Res Council ARC, Ctr Excellence Nanoscale Biophoton, Adelaide, SA, Australia; Univ Sci & Technol China, Dept Appl Chem & Engn, Hefei, Anhui, Peoples R China;

来源：FASEB JOURNAL

关键词： norbinaltorphimine; enantioselective modulation; TLR4; MD-2; morphine analgesia

年份：2019

6Targeting trimeric transmembrane domain 5 of oncogenic latent membrane protein 1 using a computationally designed peptide

作者： Wang, Yibo; Zhang, Bo; Zhang, Xiaozheng; Li, Hongyuan; Wang, Xiaohui; Wang, Yibo; Peng, Yinghua; Wilson, Andrew J.; Wilson, Andrew J.; Mineev, Konstantin S.; Wang, Xiaohui; SCI

机构： Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China; Sun Yat Sen Univ, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China; Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, State Key Lab Mol Biol Special Wild Econ Anim, Changchun 130112, Jilin, Peoples R China; Univ Leeds, Sch Chem, Woodhouse Lane, Leeds LS2 9JT, W Yorkshire, England; Univ Leeds, Astbuty Ctr Struct Mol Biol, Woodhouse Lane, Leeds LS2 9JT, W Yorkshire, England; Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia; Univ Sci & Technol China, Dept Appl Chem & Engn, Hefei 230026, Anhui, Peoples R China;

来源：CHEMICAL SCIENCE

年份：2019

7Dissecting the Innate Immune Recognition of Opioid Inactive Isomer (+)-Naltrexone Derived Toll-like Receptor 4 (TLR4) Antagonists

作者： Zhang, Xiaozheng; Chen, Hongqian; Zhang, Tianshu; Wang, Yibo; Wang, Xiaohui; Zhang, Xiaozheng; Yang, Kecheng; Zhang, Xiaozheng; Cui, Fengchao; Yang, Kecheng; Li, Yunqi; Jiang, Zhenyan; Rice, Kenner C.; Rice, Kenner C.; Watkins, Linda R.; Watkins, Linda R.; Hutchinson, Mark R.; Hutchinson, Mark R.; Peng, Yinghua; SCI

机构： Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China; Univ Chinese Acad Sci, Beijing 100039, Peoples R China; China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China; Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Synthet Rubber, Changchun 130022, Jilin, Peoples R China; Jilin Univ, Sch Pharmaceut Sci, Changchun 130021, Jilin, Peoples R China; NIDA, Drug Design & Synth Sect, Rockville, MD 20892 USA; NIAAA, NIH, Rockville, MD 20892 USA; Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA; Univ Colorado, Ctr Neurosci, Boulder, CO 80309 USA; Univ Adelaide, Adelaide Med Sch, Discipline Physiol, Adelaide, SA 5005, Australia; Univ Adelaide, ARC Ctr Excellence Nanoscale Biophoton, Adelaide, SA 5005, Australia; Chinese Acad Agr Sci, Inst Special Wild Econ Anim & Plants, State Key Lab Mol Biol Special Econ Anim, Changchun 130112, Jilin, Peoples R China;

来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING

年份：2018

8C. elegans as an in vivo model system for the phenotypic drug discovery for treating paraquat poisoning

作者： Ji, Peng; Zhao, Lihui; Li, Hongyuan; Jin, Yushan; Jin, Yushan; Peng, Yinghua; Wang, Xiaohui; Wang, Xiaohui; SCI

机构： Changchun Univ Sci & Technol, Coll Life Sci & Technol, Changchun, Peoples R China; Chinese Acad Sci, Changchun Inst Appl Chem CIAC, Biol Chem Lab, Changchun, Peoples R China; Univ Toronto, Dept Immunol, Toronto, ON, Canada; Univ Toronto, Dept Cell & Syst Biol, Toronto, ON, Canada; Chinese Acad Agr Sci, Key Lab Special Anim Mol Biol Jilin Prov, Specialty Res Inst, Changchun, Peoples R China; Univ Sci & Technol China, Dept Appl Chem & Engn, Hefei, Peoples R China; Beijing Natl Lab Mol Sci, Beijing, Peoples R China;

来源：PEERJ

关键词： Paraquat; C; elegans; Phenotypic drug discovery; Coenzyme Q10

年份：2022

9Cannabidivarin alleviates alpha-synuclein aggregation via DAF-16 in Caenorhabditis elegans

作者： Wang, Fangru; Jin, Ting; Zhao, Lihui; Li, Hongyuan; Wang, Xiaohui; Long, Houfang; Liu, Cong; Liu, Ying; Peng, Yinghua; Jin, Sha; Lu, Yuyuan; Wang, Xiaohui; Wang, Xiaohui; SCI

机构： Changchun Univ Sci & Technol, Coll Life Sci & Technol, Changchun 130012, Peoples R China; Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China; Chinese Acad Sci, Shanghai Inst Organ Chem, Interdisciplinary Res Ctr Biol & Chem, Shanghai, Peoples R China; Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, State Key Lab Mol Biol Special Econ Anim, Changchun, Peoples R China; Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun, Peoples R China; Univ Sci & Technol China, Sch Appl Chem & Engn, Hefei, Peoples R China; Beijing Natl Lab Mol Sci, Beijing, Peoples R China;

来源：FASEB JOURNAL

关键词： Caenorhabditis elegans; cannabidivarin; DAF-16; Parkinson's disease; reactive oxygen species

年份：2023

10Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling

作者： Li, Hongyuan; Lin, Cong; Zhang, Xiaozheng; Zhang, Tianshu; Wang, Yibo; Li, Yuanpeng; Wu, Siru; Wang, Hongshuang; Wang, Xiaohui; Peng, Yinghua; Hutchinson, Mark R.; Watkins, Linda R.; Watkins, Linda R.; Wang, Xiaohui; Hutchinson, Mark R.; SCI

机构： Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol, Changchun 130022, Jilin, Peoples R China; Chinese Acad Agr Sci, Inst Special Anim & Plant Sci, Changchun 130112, Jilin, Peoples R China; Univ Adelaide, Adelaide Med Sch, Discipline Physiol, Adelaide, SA, Australia; Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA; Univ Colorado, Ctr Neurosci, Boulder, CO 80309 USA; Univ Sci & Technol China, Dept Appl Chem & Engn, Hefei 230026, Peoples R China; Univ Adelaide, ARC Ctr Excellence Nanoscale Biophoton, Adelaide, SA 5000, Australia;

来源：INNOVATION

关键词： nicotine; cotinine; Toll-like receptor 4; myeloid differentiation protein 2; microglia; molecular dynamics simulation

年份：2021