Proteomic and Metabolomic Characterization of SARS-CoV-2-Infected Cynomolgus Macaque at Early Stage

文献类型： 外文期刊

第一作者： Wang, Tiecheng

作者： Wang, Tiecheng;Miao, Faming;Li, Liang;Zhang, Cheng;Yang, Guang;Xiang, Haiyang;Meng, Keyin;Wan, Zhonghai;Li, Nan;Tu, Changchun;Liu, Yan;Gao, Yuwei;Wang, Tiecheng;Miao, Faming;Li, Liang;Tu, Changchun;Liu, Yan;Gao, Yuwei;Lv, Shengnan;Wei, Feng;Zhang, Jian;Hou, Lihua;Wang, Busen;Sun, Renren;Li, Wei;Feng, Guodong;Zhao, Zhongpeng;Luo, Deyan;Wang, Hui;Xue, Xiaochang

作者机构：

关键词： SARS-CoV-2 infection; immune response; cynomolgus macaque; the early stage; proteomics; metabolomics

期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：8.786； 五年影响因子：8.876 ）

ISSN： 1664-3224

年卷期： 2022 年 13 卷

页码：

收录情况： SCI

摘要： Although tremendous effort has been exerted to elucidate the pathogenesis of severe COVID-19 cases, the detailed mechanism of moderate cases, which accounts for 90% of all patients, remains unclear yet, partly limited by lacking the biopsy tissues. Here, we established the COVID-19 infection model in cynomolgus macaques (CMs), monitored the clinical and pathological features, and analyzed underlying pathogenic mechanisms at early infection stage by performing proteomic and metabolomic profiling of lung tissues and sera samples from COVID-19 CMs models. Our data demonstrated that innate immune response, neutrophile and platelet activation were mainly dysregulated in COVID-19 CMs. The symptom of neutrophilia, lymphopenia and massive "cytokines storm", main features of severe COVID-19 patients, were greatly weakened in most of the challenged CMs, which are more semblable as moderate patients. Thus, COVID-19 model in CMs is rational to understand the pathogenesis of moderate COVID-19 and may be a candidate model to assess the safety and efficacy of therapeutics and vaccines against SARS-CoV-2 infection.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序