Immunomodulatory Effect of Isocaloric Diets with Different Protein Contents on Young Adult Sprague Dawley Rats

文献类型： 外文期刊

第一作者： Wu, Liuting

作者： Wu, Liuting;Xi, Yuyue;Tang, Zhiru;Xu, Yetong;Pang, Jiaman;Peng, Xie;Sun, Weizhong;Sun, Zhihong;An, Rui;Li, Tiejun

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关键词： SD rats; dietary protein content; immune cells; TLR4/NF-kappa B; immunological status

期刊名称：FOODS （ 影响因子：5.2； 五年影响因子：5.5 ）

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年卷期： 2023 年 12 卷 8 期

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收录情况： SCI

摘要： To understand the potential mechanisms of dietary protein on intestinal and host health, we studied the immunomodulatory effects of isocaloric diets with high or low crude protein (CP) contents on young adult Sprague Dawley (SD) rats. A total of 180 healthy male rats were randomly assigned to six groups (six replicate pens per treatment with five rats per pen) and fed diets with 10% CP, 14% CP, 20% CP (control), 28% CP, 38% CP, and 50% CP. Compared with the control diet, the rats fed the 14% CP diet significantly elevated lymphocyte cell counts in the peripheral blood and ileum, whereas the 38% CP diet significantly activated the expression of the TLR4/NF-kappa B signaling pathway in the colonic mucosa (p < 0.05). Moreover, the 50% CP diet reduced growth performance and fat deposition and increased the percentages of CD4(+) T, B, and NK cells in the peripheral blood and the colonic mucosal expression of IL-8, TNF-alpha, and TGF-beta. Overall, rats fed the 14% CP diet enhanced host immunity by increasing the numbers of immune cells, and the immunological state and growth of SD rats were negatively impacted by the diet containing 50% CP.

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